A comparison of cardiopulmonary exercise test and 6 minute walking test in determination of exercise capacity in chronic obstructive pulmonary disease
Giriş: Bu ara ş tırmada kronik obstrüktif akciğer hastalığı (KOAH)olan olgularda 6 dakika yürüme testi (6DYT) ile kardiyopulmoneregzersiz testi (KPET) arasındaki ilişkiyi ve bu iki egzersiz testininsolunum fonksiyonları aras ındaki iliş kiyi ara ştırmak amaçlanm ıştır.Materyal ve Metod: Orta ve a ğır dereceli KOAHı olan 36 (35 erkek, 1 kadın) olguya ayrıntılı solunum fonksiyon testleri 6DYT veKPET yapılm ış tır.Bulgular: Maksimal oksijen tüketimi 6 dakika yürüme mesafesi ile ilişkilidir. Her iki egzersiz testi de solunum fonksiyonları ile ilişkigöstermektedir. Ancak, maksimum egzersiz kapasitesi solunum fonksiyonları ile istatistiksel olarak daha anlamlı ilişki göstermektedir.İki test de statik akciğer hacimleri ile ilişkilidir. İnspiratuar kapasite 6DYT ve KPET parametreleriyle ilişkilidir. KPET difüzyon kapasitesi ve maksimal inspiratuar basınç ile iliş kili saptan ırken, 6DYT ile ilişki görülmemiş tir. Hava yolu iletimi ve direnci testleri ile egzersiztestleri arasında iliş ki saptanmam ış tır.Sonuç: Basit bir test olan 6DYT KOAHda egzersiz kapasitesini belirlemede kullan ılabilir. Her iki test de ventilatuar bozuklu ğu gösteren özellikle FEV1 , maksimum volenter ventilasyon (MVV) ve inspiratuar kapasite ile belirlenen solunum fonksiyon testleri ile ilişkilidir.Ancak, CPET hiperinflasyonu ve solunum kas gücünü daha iyi de ğerlendiren ve 6DYTden daha ayrıntılı sonuçlar veren bir egzersiztestidir.
KOAH'ta egzersiz kapasitesinin belirlenmesindekardiyopulmoner egzersiz testiyle 6 dakika yürüme testinin karşılaştırılması
Introduction: This study aimed to determine the relationship of 6 minute walking test (6MWT) and cardiopulmonary exercise test(CPET) with each other and with the measures of lung functions in patients with chronic obstructive pulmonary disease (COPD).Materials and Methods: Pulmonary function tests, 6MWT, and CPET were performed in 36 (35 males, 1 female) patients with mod-erate and severe COPD.Results: Maximum oxygen uptake was significantly correlated with 6 minute walking distance. Both exercise tests were correlatedwith pulmonary function tests. However, maximum exercise capacity was more closely correlated with measures of lung functionthan 6MWT. Both tests were significantly correlated with static lung volumes. Inspiratory capacity (IC) was significantly correlatedwith 6MWT and CPET parameters. CPET was significantly correlated with diffusion capacity and maximal inspiratory pressure. Airwayconductance and resistance tests showed no correlation with the exercise tests.Conclusion: 6MWT is a simple and valuable test to determine the exercise capacity of COPD patients. Both 6MWT and CPET arecorrelated with ventilatory impairment determined by the lung function tests, particularly FEV1 , maximum voluntary ventilation(MVV), and IC. However, CPET is an exercise test that more accurately evaluates and provides more detailed information abouthyperinflation and respiratory musce strength than 6MWT does.
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- 1. Brown CD, Wise RA. Field tests of exercise in COPD: The six-minute walk test and shuttle walk test. COPD 2007;4:217-23.
- 2. Diaz O, Villafranca C, Ghezzo H, Borzone G, Leiva A, Milic-Emil, J, et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal expira- tory flow limitation at rest. Eur Respir J 2000;16:269-75.
- 3. Ortega F, Montemayor T, Sanchez A. Role of cardiopulmo- nary exercise testing and criteria used to determine disabil- ity in patients with severe COPD. Am J Respir Crit Care Med 1994;150:747-51.
- 4. Butland RJA, Pang J, Gross ER, Woodcock AA, Geddes DM. Two, six and, twelve minute walk tests in respiratory disease. BMJ 1982;84:1607-8.
- 5. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Lung Disease (revised 2011), www.goldcopd.com
- 6. American Thoracic Society. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002;166:111-7.
- 7. Sciurba F, Criner GJ, Lee SM, Mohsenifar Z, Shade D, Slivka W et al. Six minute walk distance in chronic obstruc- tive pulmonary disease. Am J respir Crit Care Med 2003;167:1522-7.
- 8. Guyatt GH, Thompson PJ, Berman LB, Sullivan MJ, Townsend M, Jones NL, et al. How should we measure function in patients with chronic heart and lung disease? J Chronic Dis 1985;38:517-24.
- 9. Solway S, Brooks D, Lacasse Y, Thomas S. A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest 2001;119:256-70.
- 10. Calverley PMA, Pearson MG. Clinical and laboratory assessment in chronic obstructive pulmonary disease. In: Calverley PMA, Mac Nee W, Pride NB, Rennard SI (eds). London: Arnold, 2003:282-309.
- 11. Killian KJ, Summers E, Jones NL. Dyspnea and leg effort during incremental cycle ergometry. American Rev Respir Dis 1992;145:1339-45.
- 12. Hamilton AL, Killian KJ, Summers E, Jones NL. Symptom intensity and subjective limitation to exercise in patients with cardiorespiratory disorders. Chest 1996;110:1255-63.
- 13. Ambrosino N, Scano G. Measurement and treatment of dyspnoea. Respir Med 2001;95:539-47.
- 14. Enright PL, Sherill DL. Referans equations fort he six minute walk in healty adults. Am J Respir Crit Care Med 1998;158:1384-7.
- 15. Troosters T, Gosselink R, Decramer M. Six minute walking distance in healty elderly subjects. Eur Respir J 1999;14:270.
- 16. Gibbons WJ, Fruchter N, Sloan S, levy RD. Reference val- ues for a multiple repetition 6-minute walk test in healty adults older than 20 years. J cardiopulm Rehabil 2001;21:87-93.
- 17. Fletcher GF. Exercise Standards for Testing and Training. A Statement for Healthcare Professionals From the American Heart Association. Circulation 2001;104:1694-740.
- 18. Casa A, Vilaro J, Robinovich R. Encouraged 6-min walking test indicates maximum sustainable exercise in COPD patients. Chest 2005;128:55-61.
- 19. Turner SE, Eastwood PR, Cecins NM, Hillman DR, Jenkins SC. Pysiologic responses to incremental and self paced exercise in COPD: a comparison of tree tests. Chest 2004;126:766-73.
- 20. Ong KC, Earnest A, Lu SJ. A multidimensional grading sys- tem (BODE index) as predictor of hospitalization for COPD. Chest 2005;128:3810-16. 21. TenVergert EM, Wijkstra PJ, van der Mark TW, Postma DS, Van Altena R, Kraan J, et al. Relation of lung function, maximal inspiratory pressure, dyspnoea, and quality of life with exercise capacity in patients with chronic obstructive pulmonary disease. Thorax 1994;49:468-72.
- 22. Berry MJ, Adair NE, Rejeski WJ. Use of peak oxygen con- sumption in predicting physical function and quality of life in COPD patients. Chest 2006;129:1516-22.
- 23. Ulubay G, Gorek A, Savas S, Oner Eyuboglu F. Evaluation of dynamic hyperinflation parameters and exercise capac- ity at maximal exercise in patients with COPD. Tuberk toraks 2005;53:340-6.
- 24. Carter R, Peavler M, Zinkgraf S, Williams J, Fields S. Predicting maximal exercise ventilation in patients with chronic obstruc- tive pulmonary disease. Chest 1987;92:253-9.
- 25. Marin JM, Carrizo SJ, Gascon M. Inspiratory capacity, dynamic hyperinflation, breathlessness and exercise perfor- mance during the six minute walking test in COPD. Am J Respir Crit Care Med 2001;163:1395-9.
- 26. Fink G, Lebzelter J, Turner D, Klainman E, Shlomo M, Katz I, et al. Pulmonary function threshold for distinguishing ventilatory- and nonventilatory-limited patients with airflow obstruction. Respir Med 1998;92:1245-50.
- 27. LoRusso TJ, Belman MJ, Elashoff JD, Koerner SK. Prediction of maximal exercise capacity in obstructive and restrictive pulmonary disease. Chest 1993;104:1748-54.
- 28. Marthan R, Castaing Y, Manier G, Guenard H. Gas Exchange alterations in patients with chronic obstructive lung disease. Chest 1985;87:470-5.
- 29. Wasserman K, Sue DY, Oren A, Hansen JE. Diffusing capacity for carbon monoxide as a predictor of gas exchange during exercise. N Engl J Med 1987;316:1301-6.
- 30. Mak VHF, Bugler JR, Roberts CM, Spiro SG. Effect of arte- rial oxygen desaturation on six minute walk distance, per- ceived effort, and perceived breathlessness in patients with airflow limitation. Thorax 1993;48:33-8.
- 31. Jones NL, Jones G, Edwards RHT. Exercise tolerance in chronic airway obstruction. Ani Rev Respir Dis 1971;103:447-91.
- 32. Akkoca O, Demir G, Saryal S, Karab ıyıkoglu G. The effect of hyperinflation on respiratory muscles and breathing pat- tern in COPD. Tuberk Toraks 2003;51:244-52.