Small large-cell neuroendocrine carcinoma in a patient with pulmonary emphysema
Büyük hücreli nöroendokrin kanserler göreceli olarak nadirdir ve sıklıkla daha büyük tümörler olarak ortaya çıkar. Bu yazıda, amfizemi olan 63 yaşında bir erkek hastada küçük bir büyük hücreli nöroendokrin kanser olgusu bildiriyoruz. Periferik parankimal nodülde lobülasyon ve spiküle uzanımlar yoktu, küçük boyutu ve çevreleyen amfizemin etkisiyle cerrahi öncesinde doğru tanıyı koymak güçtü.
Amfizemli bir hastada küçük bir büyük hücreli nöroendokrin kanser
Large-cell neuroendocrine carcinomas (LCNECs) are relatively rare, and most reported occurrences tend to involve relatively large tumors. We report a small LCNEC in a 63-year-old male patient with pulmonary emphysema. The peripheral pulmonary nodule did not have lobulation and spiculation, and it was difficult to establish correct diagnosis before surgery because of its small size and effect of surrounding emphysematous change.
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- 1. Travis WD, Linnoila RI, Tsokos MG, et al. Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma. An ultrastructural, immunohistochemical and flow cytomertic study of 35 cases. Am J Surg Pathol 1991; 15: 529-53.
- 2. World Health Organization. Histopathological Typing of Lung and Pleural Tumours. 3rd ed. Berlin: Springer, 1999.
- 3. Takei H, Asamira H, Maeshima A, et al. Large cell neuroendocrine carcinoma of the lung: A clinicopathological study of eighty-seven cases. J Thoracic Cardiovasc Surg 2002; 124: 285-92.
- 4. Zacharias J, Nicholson AG, Ladas GP, Goldstraw PG. Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: Prognosis after complete resection and systemic nodal dissection. Ann Thoracic Surg 2003; 75: 348-52.
- 5. Rossi G, Cavazza C, Marchioni A, et al. Role of chemotherapy and the receptor tytosine kinase KIT, PDGFRα, PDGFRβ, and Met in large-cell neuroendocrine carcinoma of the lung. J Clin Oncol 2005; 23: 8774-85.
- 6. Shin AR, Shin BK, Choi JA, Oh YW, Kim HK, Kang EY. Large cell neuroendocrine carcinoma of the lung: Radiologic and pathologic findings. J Comput Assist Tomogr 2000; 24: 567-73.
- 7. Jung KJ, Lee KS, Han JH, et al. Large cell neuroendocrine carcinoma of the lung: Clinical, CT, and pathologic findings in 11 patients. J Thorac Imaging 2001; 16: 156-62.
- 8. Iyoda A, Hiroshima K, Moriya Y, et al. Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity. Ann Thoracic Surg 2004; 77: 1891-5.
- 9. Hanaoka T, Sone S, Ino H, et al. Subcentimeter large cell neuroendocrine carcinoma of the lung. J Thoracic Imaging 2005; 20: 288-90.
- 10. Oshiro Y, Kusumoto M, Matsuno Y, et al. CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients. AJR 2004; 182: 87-91.
- 11. Chong S, Lee KS, Chung MJ, Han J, Kwon OJ, Kim TS. Neuroendocrine tumors of the lung: Clinical, pathologic, and imaging findings. Radiographics 2006; 26: 57-8.
- 12. Matsuoka S, kurihara Y, Yagihashi H, Nakajima Y. Peripheral solitary pulmonary nodule: CT findings in patients with pulmonary emphysema. Radiology 2005; 235: 255-73.