Skin metastasis from small cell lung cancer
Cilt metastazı olan olgularda daima birçok organda yaygın metastazlar bulunmaktadır. Burada, küçük hücreli akciğer kanser (KHAK)'li ve cilt metastazlı nadir görülen bir olgu sunulmaktadır. Hasta platin- bazlı kemoterapi ile tedavi edildi ve tedavi yanıtı, parsiyel yanıt olarak değerlendirildi. Hastalık yavaş seyirli bir progresyon gösterdi ve olgu tanıdan 16 ay sonra kaybedildi. KHAK'li hastalarda tipik olsun olmasın deri lezyonları saptandığında, biyopsi düşünülmelidir. En sık tutulum bölgesi gövde olmasına rağmen, KHAK'li hastalarda böyle lezyonlar görüldüğünde şüphelenilmesi önemlidir.
Küçük hücreli akciğer kanseri, cilt metastazı
Patients with skin metastasis always had disseminated metastases in many organs. We herein report an unusual case with skin metastasis from small cell lung cancer (SCLC). The patient was treated with platinum-containing chemotherapy, and the response to the therapy was evaluated as partial response. The patient had slowly progressive disease and died of SCLC 16 months after the diagnosis of the diseases. If skin lesions, whether it may be typical or not, are found in SCLC patients, biopsy from the lesion would be considered to perform. Although trunk may be the most common sites, it is important to suspect such metastasis occurs in patients with SCLC.
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- 1. Matsukawa A, Furusugi Y. A case of skin metastasis of lung carcinoma associated with superior vena cava syndrome. J Dermatol 1989;16:508-10.
- 2. Coslett LM, Katlic MR. Lung cancer with skin metastasis. Chest 1990;97:757-9.
- 3. Maeda J, Miyake M, Tokita K, Iwahashi N, Nakano T, Tamura S, et al. Small cell lung cancer with extensive cutaneous and gastric metastases. Intern Med 1992;31:1325-8.
- 4. Terashima T, Kanazawa M. Lung cancer with skin metastasis. Chest 1994;106:1448-50.
- 5. Hidaka T, Ishii Y, Kitamura S. Clinical features of skin metastasis from lung cancer. Intern Med 1996;35:459-62.
- 6. De Argila D, Bureo JC, Márquez FL, Pimentel JJ. Small-cell carcinoma of the lung presenting as a cutaneous metastasis of the lip mimicking a Merkel cell carcinoma. Clin Exp Dermatol 1999;24:170-2.
- 7. D'Aniello C, Brandi C, Grimaldi L. Cutaneous metastasis from small cell lung carcinoma. Case report. Scand J Plast Reconstr Surg Hand Surg 2001;35:103-5.
- 8. Senen D, Adanali G, Tuncel A, Erdoğan B. Oat cell lung cancer diagnosed following metastasis to the skin. Plast Reconstr Surg 2003;111:510-1.
- 9. Barbetakis N, Samanidis G, Paliouras D, Samanidou E, Tzimorota Z, Asteriou C, et al. Facial skin metastasis due to small-cell lung cancer: a case report. J Med Case Rep 2009;3:32.
- 10. Dhambri S, Zendah I, Ayadi-Kaddour A, Adouni O, El Mezni F. Cutaneous metastasis of lung carcinoma: a retrospective study of 12 cases. J Eur Acad Dermatol Venereol 2011;25:722-6.
- 11. Simsek GG, Karadag AS, Turksen Z. Cutaneous metastasis of the small cell lung cancer. Indian J Dermatol Venereol Leprol 2011;77:537.
- 12. Marcoval J, Penín RM, Llatjós R, Martínez-Ballarín I. Cutaneous metastasis from lung cancer: Retrospective analysis of 30 patients. Australas J Dermatol 2012;53:288-90.