Küçük hücreli dışı akciğer kanserinde nodal evrelemede invaziv prosedürlerin üstünlükleri

Küçük hücreli dışı akciğer kanserinde evreleme; tedavi şekli ve prognozu etkileyen en önemli faktördür. Tedavi stratejisi hastanın klinik durumuna, preoperatif, intraoperatif ve postoperatif patolojik evreleme sonucuna göre ciddi farklılıklar içerir. Günümüzde preoperatif histopatolojik tanı bir zorunluluk halini almıştır. Kesin doku tanısına ulaşmak invaziv tekniklerin kullanımını gerektirir. Hastalık varlığını kanıtlamak ve olası torakotomiye gidecek hastada eğer varsa kontrlateral metastaz olasılığını değerlendirmek amacıyla invaziv evreleme ve tanı yöntemleri günümüzde yaygın olarak kullanılmaktadır. Preoperatif dönemde okült N2 hastalığı ortaya çıkaracak invaziv evreleme metotlarından sonuna kadar faydalanmak hastaların yararına olmaktadır.

The superiorities of invasive procedures in nodal staging of non-small cell lung cancers

The staging of non-small cell lung cancer is the most important factor that affects the treatment form and prognosis. The management strategy includes serious variations according to clinical condition of the patient, preoperative, intraoperativeand postoperative pathologic staging outcomes. Today, obtaining the histopathological diagnosis preoperatively became mandatory. Reaching the definite tissue diagnosis requires the using of invasive technics. Nowadays; there is a widespreaduse of invasive staging and diagnostic procedures in order to show the evidence of disease presence and determine the probability of contralateral metastasis in a patient who will undergo a possible thoracotomy. In the preoperative period, benefiting from the invasive staging methods that will reveal occult N2 disease totally, would be more useful for the patients.

___

  • 1. Mountain CF. Revisions in the international system for staging lung cancer. Chest 1997; 111: 1710-7.
  • 2. Naidich DP, Webb WR, Müller NL, Krinsky GA (eds). Lung Cancer. Computed Tomography and Magnetic Resonance of The Thorax. 3rd ed. Philadelphia: Lippincott-Raven, 1999: 343-80.
  • 3. Miller TW. Radiographic, computed tomographic and magnetic resonance investigation of the mediastinum. In: Shields TW (ed). General Thoracic Surgery. 5th ed. Vol 2. Philadelphia: Lippincott Williams & Wilkins, 2000: 2009-32.
  • 4. Fultz PJ, Feins RH. Radiologic Evaluation of Lung Cancer. In: Shields TW (ed). General Thoracic Surgery. 5th ed. Vol(1). Philadelphia: Lippincott Williams & Wilkins, 2000: 1283-96.
  • 5. Glazer GM, Gross BH, Quint LE, Francis IR, Bookstein FL, Orringer MB. Normal mediastinal lymph nodes: Number and size according to ATS mapping. AJR Am J Roentgenol 1985; 144: 261-5
  • 6. Buy JN, Ghossain MA, Poirson F, et al. CT of mediastinal lymph nodes in NSCLC. A new approach based on the lymphatic pathway of tumor spread. J Comp Assist Tomogr 1988; 12: 545-52.
  • 7. Staples CA, Muller NL, Miller RR, et al. Mediastinal nodes in bronchogenic carcinoma: Comparison between CT and mediastinoscopy. Radiology 1988; 167: 367-72.
  • 8. Libshitz HI, McKenna RJ. Mediastinal lymph node size in lung cancer. AJR Am J Roentgenol 1984; 143: 715-8.
  • 9. Seely JM, Mayo JR, Miller RR, Muller NL. T1 lung cancer: Prevalance of mediastinal nodal metastases and diagnostic accuracy of CT. Radiology 1993; 186: 129-32.
  • 10. McCloud TC, Bourgoin PM, Greenberg RW. Bronchogenic carcinoma: Analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling. Radiology 1992; 182: 319-23.
  • 11. Sönmezoğlu K. Akciğer kanserlerinde FDG-PET uygulamaları. Tuberk Toraks 2005; 53: 95-114.
  • 12. Pieterman R, VanPutten J, Meuzelaar J, et al. Preoperative staging of non-small-cell lung cancer with positron emission tomography. N Engl J Med 2000; 343: 254-61.
  • 13. Saunders CAB, Dussek JE, O’Doherty MJ, et al. Evaluation of fluorine-18-fluorodeoxyglucose whole body positron emission tomography in the staging of lung cancer. Ann Thorac Surg 1999; 67: 790-7.
  • 14. Gambhir S, Czernin J, Schwimmer J, et al. A tabulated summary of the FDG PET literature. J Nucl Med 2001; 42: 1-92.
  • 15. Dwamena BA, Sonnad SS, Angobaldo JO, et al. Metastases from non-small cell lung cancer: Mediastinal staging in the 1990s; meta-analytic comparison of PET and CT. Radiology 1999; 213: 530-6.
  • 16. Toloza EM, Harpole L, McCrory D. Noninvasive staging of non-small cell lung cancer: A review of the current evidence. Chest 2003; 123: 137-46.
  • 17. Dietlein M, Weber K, Gandjour A, et al. Cost-effectiveness of FDG-PET for the management of potentially operable nonsmall cell lung cancer; priority for a PET-based strategy after nodal-negative CT results. Eur J Nucl Med 2000; 27: 1598-609.
  • 18. MacKenzie JW, Riley DJ. diagnostic and staging procedures: Mediastinal evaluation, scalene lymph node biopsy, mediastinoscopy, mediastinotomy. In: Baue AE (ed). Glenn’s Thoracic and Cardiovascular Surgery. 6th ed. Stamford: Appleton and Lange, 1996: 181-90.
  • 19. Lewis RJ, Sisler GE, Mackenzie JW. Mediastinoscopy in advanced superior vena cava obstruction. Ann Thorac Surg 1981; 32: 458-62.
  • 20. Jahangiri M, Goldstraw P. The role of mediastinoscopy in superior vena caval obstruction. Ann Thorac Surg 1995; 59: 453-5.
  • 21. Meersschaut D, Vermassen F, Riviere AB, et al. Repeat mediastinoscopy in the assesment of new and recurrent lung neoplasm. Ann Thorac Surg 1992; 53: 120-2.
  • 22. Bocage JP, Mackenzie JW. Invazive Diagnostic Procedures. In: Shields TW (ed). General Thoracic Surgery. 5th ed. Vol 1. Philadelphia: Lippincott Williams & Wilkins, 2000: 273-84.
  • 23. Shields TW. Diagnosis and staging of lung cancer. In: Baue AE (ed). Glenn’s Thoracic and Cardiovascular Surgery. 6th ed. Stamford: Appleton and Lange, 1996: 391-420.
  • 24. Reed CE, Silvestri GA. Diagnosis and staging of lung cancer. In: Shields TW (ed). General Thoracic Surgery. 5th ed. Vol 1. Philadelphia: Lippincott Williams & Wilkins, 2000: 1297-310.
  • 25. Rendina EA, Venuta F, Giacomo TD, et al. Comparative merits of thoracoscopy, mediastinoscopy and mediastinotomy for mediastinal biopsy. Ann Thorac Surg 1994; 57: 992-5.
  • 26. Nakanishi R, Yasumoto K. Combined thoracoscopy and mediastinoscopy for mediastinal lymph node staging of lung cancer. Int Surgery 1996; 81: 359-61.
  • 27. Lin JC, Landreneau RJ. VATS for mediastinal tumors and cysts and other diseases within the mediastinum. In: Shields TW (ed). General Thoracic Surgery. 5th ed. Vol 2. Philadelphia: Lippincott Williams & Wilkins, 2000: 2079-92.
  • 28. Pearson FG, DeLarue NC, Ilves R, et al. Significiance of positive superior mediastinal nodes identified at mediastinoscopy in patients with resectable cancer of the lung. J Thorac Cardiovasc Surg 1982; 83: 1-11.
Tüberküloz ve Toraks-Cover
  • ISSN: 0494-1373
  • Yayın Aralığı: 4
  • Başlangıç: 1951
  • Yayıncı: Tuba Yıldırım
Sayıdaki Diğer Makaleler

Recurrent pneumothorax at an infant with miliary tuberculosis

Resul YILMAZ, M. Ayşin TAŞAR, Sinan ASLAN, İlknur BOSTANCI, Yıldız DALLAR

Afyonkarahisar ili ilköğretim okulu öğrencilerinde habitüel horlama ve uyku ile ilişkili solunum bozukluğu prevalansı

Mehmet ÜNLÜ, Murat SEZER, Fatma FİDAN, Ziya KARA

KOAH olgularında beslenme durumu, solunum fonksiyonları ve egzersiz performansı

Murat ÖGETÜRK, Canan KAÇAR, Gamze KIRKIL, Teyfik TURGUT, M. Hamdi MUZ, Figen DEVECİ, Tuncer TUĞ

The relationship between pulmonary function tests, thorax HRCT, and quantitative ventilation-perfusion scintigraphy in chronic obstructive pulmonary disease

Hande İKİTİMUR, Özlem ÖZMEN, Bedii KANMAZ, Nurhayat YILDIRIM, Birsen MUTLU, Tunçalp DEMİR, Canan AKMAN, Akpınar Sibel TEKGÜNDÜZ

Küçük hücreli dışı akciğer kanserinde nodal evrelemede invaziv prosedürlerin üstünlükleri

Arif Osman TOKAT, Serkan ENÖN, Adem GÜNGÖR

KOAH’lı olgularda kardiyopulmoner egzersiz testi ile egzersiz kapasitesi ve dinamik hiperinflasyonun değerlendirilmesi

Aslı GÖREK, Gaye ULUBAY, Şerife SAVAŞ, Öner Füsun EYÜBOĞLU

Sigarayı bırakmada nikotin replasman tedavisi ve davranış eğitimi yöntemlerinin karşılaştırılması: Doğal izlem çalışması

Bahar KURT, Osman ÖRSEL, Sibel ALPAR, Nazire UÇAR, Sibel ÖRSEL, Tuğrul ŞİPİT

Spontaneous sternoclavicular joint infection

Cabir YÜKSEL, Kayı Ayten CANGIR, Şevket KAVUKÇU

Elazığ merkezinde oto ve mobilya atölyelerinde çalışan boya işçilerinde mesleki astım sıklığı

Canatan TAŞDEMİR, Gamze KIRKIL, Teyfik TURGUT, M. Hamdi MUZ, Figen DEVECİ

Distribution of Bcl-2 gene expression and its prognostic value in non-small cell lung cancer

Akın KAYA, Berna SAVAŞ, Ayşe YILMAZ, Adem GÜNGÖR, İsmail SAVAŞ, Ebru SERİNSÖZ, Dizbay Serpil SAK