Ayşe Bilge ÖZTÜRK, Zeki KILIÇASLAN, Halim İŞSEVER

Effect of smoking and indoor air pollution on the risk of tuberculosis: Smoking ,indoor air pollution and tuberculosis

Giriş: Epidemiyolojik çalış malar sigara ile tüberküloz artışı arasında bir ilişki bildirmesine ra ğmen, iç ortam hava kirliliği ve tüberkülozarasındaki ilişki net olarak anlaşılmış de ğildir. Sın ırlı sayıdaki çalışmalar sigara ve iç ortam hava kirliliğinin tüberküloz patogenezinderol oynayabilece ğini düşündürmektedir. Bu çalışmada, sigara ve iç ortam hava kirliliğinin aktif tüberküloz riski üzerine olan etkisiniaraştırdık.Materyal ve Metod: Bu prospektif, yaşa göre eşleştirilmiş bir olgu kontrol çalışmasıdır. Üç yüz altmış iki aktif tüberkülozlu ve 409sa ğlıklı kontrol çalışmaya dahil edildi. Tüm katılımc ılara yüz yüze sigara içme alışkanlı ğı , miktarı ve sigara içme süresi, kişi başınadüşen oda sayısı , ailenin aylık geliri, ısınma sistemi ve çevresel tütün duman ı maruziyetini içeren bir anket formu dolduruldu.Bulg ular: Sigara içen hastalar sigara içmeyen hastalara kıyasla 5 kat daha fazla aktif tüberküloz riskine sahipti (%95 CI: 3.2-7.5, p

Sigara ve iç ortam hava kirliliğinin tüberküloza etkisi: Sigara, tüberküloz, iç ortam hava kirliliği

E ffect o f Smoking and Indoor Air Pollution on the Risk o f Tuberculosis: Smoking, Indoor Air Pollution and TuberculosisIntroduction: Although epidemiological studies have reported an association between smoking and increases in tuberculosis thes,relationship between indoor air pollution and risk of tuberculosis is not fully understood. A limited number of studies have sugge ste desthat smoking and indoor air pollution may play a role in the pathogenesis of tuberculosis. In this study, we investigated the effe ct ofecsmoking and indoor air pollution on the risk of active tuberculosis.Materials and Methods: It is prospectively recorded age matched case-control study. Three hundred sixty two active tubercu losisulcases and 409 healthy controls were included to the study. All participants were interviewed face to face by using a question n airenincluding smoking habit, quantity and duration of smoking, number of room/person in the house, monthly income of the fa m ily,mindoor heating system, and environmental tobacco smoke.Results: Patients who smoke had a five fold (95% CI: 3.2-7.5, p< 0.0001) higher odds of havin g active tuberculosis compared w ithwpatients who do not smoke. Similarly, patients usin g coal or wood for indoor heatin g had a 1.6 fold (95% CI: 1.179-2.305, p< 0. 0 03)0higher odds havin g tuberculosis. People who have less income (< 200 Euro/month) had 3.2 fold (95% CI: 2.113-5.106, p< 0.0001) higher odds of havin g tuberculosis compared with people havin g high income. There was a significant correlation between heavy smokin g (≥ 20 packet/year, p< 0.0001) and a ge onset of smokin g (< 16 years of a ge, p< 0.041). There was no significant association between environmental tobacco smoke and tuberculosis.

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