Hasan ERSÖZ, Ahmet ÖNEN, Atilla AKKOÇLU, Elvan YILMAZ, Sevgi ÖZALEVLİ, Ayşe YEĞİN

Comparison of health-related quality of life and exercise capacity according to stages in patients with non-small cell lung cancer

Giriş: Çalışmamızın amacı; küçük hücreli dışı akciğer kanseri (KHDAK) hastalarında egzersiz kapasitesi ve sağlıkla ilgili yaşam kalitesi parametrelerini evrelere göre karşılaştırmaktır. Materyal ve Metod: Evre I-II (grup erken evre, n= 17) ve evre IIIA-IV olan (grup ileri evre, n= 35) 52 (bağımsız yürüyebilen) KHDAK hastası çalışmaya dahil edildi. Egzersiz kapasitesi (altı dakika yürüme testiyle), periferal kas kuvveti (sırt ve bacak dinamometresiyle), performans düzeyi (Karnofsky performans skalasıyla), sağlıkla ilgili yaşam kalitesi [European Organization for Research and Treatment of Cancer Yaşam Kalitesi Anketi (EORTC QLQ-C30) ve Short Form-36 (SF-36) anketiyle], depresyon ve kaygı düzeyi (Hastane Anksiyete ve Depresyon skalasıyla) değerlendirildi. Bulgular: İki grup arasında yaş, beden kitle indeksi, solunum semptomları ve hücre tipi dağılımı açısından fark bulunmadı (p> 0.05). İleri evre grupta solunum fonksiyon testi değerleri, periferal kas kuvveti, yürüme mesafesi, yaşam kalitesinin özellikle fonksiyonel kapasite ve ağrı kategorileri skorları erken evre gruba göre düşüktü (p≤ 0.05). Depresyon ve anksiyete sonuçları her iki grupta benzer bulundu (p> 0.05). Sonuç: İleri evre KHDAK hastalarında egzersiz kapasitesi; azalmış solunum fonksiyonları ve periferal kas kuvveti nedeniyle erken evre KHDAK hastalarına göre daha fazla azalmaktadır. Bu nedenlerle; KHDAK hastalarında azalmış egzersiz kapasitesinin hastaların yaşam kalitesinin özellikle fonksiyonel kategorilerini olumsuz olarak etkilediğini düşünmekteyiz.

Küçük hücreli dışı akciğer kanseri olan hastalarda evrelere göre yaşam kalitesi ve egzersiz kapasitesinin karşılaştırılması

Introduction: The aim of this study is to compare the exercise capacity and health-related quality of life parameters according to stages of patients with non-small cell lung cancer (NSCLC). Materials and Methods: Fifty-two patients (who are able to ambulate independently) with stage I-II (group early-stage, n= 17) and stage IIIA-IV NSCLC (group advanced-stage, n= 35) were included. Exercise capacity (six minute walking test), strength of the peripheral muscle (Back and Leg Dynamometer), performance status (Karnofsky performance status scale), health-related quality of life- HRQOL (European Organization for Research and Treatment of Cancer Quality of life measure and Short Form-36 Health Survey), depression and anxiety (Hospital Anxiety and Depression Scale) were evaluated. Results: No difference was found in age, body mass index, respiratory symptoms and the distribution of disease cell types between two groups (p> 0.05). In advanced-stage group, pulmonary function test values, peripheral muscle strength, walking distance and health-related quality of life scores especially the categories of functional capacity and pain were established significantly lower compared to early-stage group (p≤ 0.05). Depression and anxiety levels were confirmed to be similar between groups (p> 0.05). Conclusion: The exercise capacity of patients with advanced-stage NSCLC is lower due to reduced pulmonary functions and peripheral muscle strength compared to patients with early-stage NSCLC. Therefore, we can conclude that reduced exercise capacity negatively impacts functional categories of health related quality of life of patients with advanced-stage NSCLC.

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