İlkin ZİNDANCI, Aydanur MİHMANLI, Ahmet SELVİ, Müyesser ERTUĞRUL, Bahadır ÜSKÜL, Hatice TÜRKER

A rare association: Castleman’s disease and pemphigus vulgaris

Castleman hastalığı, etyolojisi tam olarak aydınlatılmayan, tüm vücutta bulunabilmekle beraber sıklıkla toraksta yerleşen reaktif lenf nodu hiperplazisidir. Genellikle genç erişkinlerde görülür ve asemptomatik seyreder. Sıklıkla ön ve orta mediastende lokalizedir. Pemfigus vulgaris, patogenezinde immün mekanizmaların rol oynadığı büllöz bir deri hastalığıdır. En sık ağız ve orofarenks etkilenir. Epidermal intraselüler yapılara karşı gelişen IgG antikorların varlığı teşhiste gereklidir. Castleman hastalığı ile oral pemfigus vulgaris birlikteliğinin nadir olması nedeniyle, 28 yaşında kadın olguyu literatür eşliğinde tartışmak istedik.

Nadir görülen birliktelik: Castleman hastalığı ve pemfigus vulgaris

Castleman disease is a reactive lymph node hyperplasia of unknown origin that often involving the thorax although it may involve all parts of the body. It is usually seen in young adults and presents an asymptomatic course. It is usually located to anterior and middle mediastinum. Pemphigus vulgaris is a bullous skin disease in which immune mechanisms take place in the pathögenesis. Mouth and oropharynx are the most commonly involved structures. IgG antibodies against the epidermal intracellular structures are essential in the diagnosis. We have wanted to discuss a 28 years old female with the literature review since the association between pemphigus vulgaris and Castleman's disease is rare.

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