Nazoorofarenks ve larenksi tutan nazal tip doğal katil T hücreli lenfoma

Lenfoma, baş boyun bölgesini tutan yassı hücreli olmayan malign tümörlerden biridir. Bu bölgedeki lenfomalar çoğunlukla B hücre tipi kaynaklıdır ve genellikle Waldeyer halkasında görülür. Bu yazıda, nazo-orofarenksten larenkse uzanan pri- mer nazal tip doğal katil T hücreli lenfoma tanılı 45 yaşında bir kadın olgu sunuldu. Nadir görülen bu olgu, kötü prognoza sahiptir

Nasal type natural killer T-cell lymphoma involving nasooropharynx and larynx

Lymphoma is one of the malignant non-squamous tumors involving the head and neck. Lymphomas in this region are mostly B-cell type in origin and usually seen in Waldeyer’s ring. In this article, we report a 45-year-old female case of primary natural killer T cell lymphoma-nasal type involving the nasooropharynx and larynx. This is a very rare entity with poor prognosis.

___

  • Horny HP, Kaiserling E. Involvement of the larynx by hemopoietic neoplasms an investigation of autopsy cases and review of the literature. Pathol Res Pract 1995;191:130-8.
  • Horny HP, Ferlito A, Carbone A. Laryngeal lymphoma derived from mucosa-associated lymphoid tissue. Ann Otol Rhinol Laryngol 1996;105:577-83.
  • Mok JS, Pak MW, Chan KF, Chow J, Hasselt CA. Unusual T- and T/NK-cell non-Hodgkin’s lymphoma of the larynx: a diagnostic challenge for clinicians and pathologists. Head Neck 2001;23:625-8.
  • Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC: Lyon 2008.
  • Urquhart A, Berg R. Hodgkin’s and non-Hodgkin’s lymphoma of the head and neck. Laryngoscope 2001;111:1565-9.
  • King AD, Yuen EH, Lei KI, Ahuja AT, van Hasselt A. Non-Hodgkin lymphoma of the larynx: CT and MR imaging findings. AJNR Am J Neuroradiol 2004;25:12-5.
  • Siddiqui NA, Branstetter IV BF, Hamilton BE, Ginsberg LE, Glastonbury CM, Harnsberger HR, et al. Imaging characteristics of primary laryngeal lymphoma. AJNR Am J Neuroradiol 2010;31:1261-5.
  • Yang J, Maronian N, Reyes V, Waugh P, Brentnall T, Hillel A. Laryngeal and other otolaryngologic manifestations of Crohn's disease. J Voice 2002;16:278-82.
  • Bernstein CN, Blanchard JF, Kliewer E, Wajda A. Cancer Risk in Patients with Inflammatory Bowel Disease. Cancer 2001;91:854-62.
  • Kandiel A, Fraser G, Korelitz BI, Brensinger C, Lewis JD. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005;54:1121-5.