Doğan ATAN, Kürşat Murat ÖZCAN, Sabri KÖSEOĞLU, Aykut İKİNCİOĞULLARI, Mehmet Ali ÇETİN, Serdar ENSARİ, Hüseyin DERE

Nazal polipte yeni öngörücü parametreler: Nötrofil lenfosit oranı ve trombosit lenfosit oranı

Amaç: Bu çalışmada nazal polip NP ve NP yoğunluğu ile nötrofil lenfosit oranı NLO ve trombosit lenfosit oranı TLO değerleri arasındaki ilişki araştırıldı.Hastalar ve Yöntemler: Çalışmaya NP tanısı konulmuş 105 hasta NP grup 72 erkek, 33 kadın; ort. yaş 41.33±12.85 yıl; dağılım 16-63 yıl ile 83 sağlıklı birey 54 erkek, 29 kadın; ort. yaş 44.01±8.50 yıl; dağılım 18-62 yıl kontrol grubu dahil edildi. Nazal polip yoğunluğu skoru ameliyat öncesi Lund-Mackay bilgisayarlı tomografi skorlama sistemi ile değerlendirildi. NP ve kontrol grubunun NLO ve TLO değerleri hesaplandı ve istatistiksel olarak karşılaştırıldı. NP grubunda NLO ve TLO değerleri NP yoğunluğuna göre istatistiksel olarak karşılaştırıldı.Bulgular: Ortalama NLO değeri NP grubunda 2.26, kontrol grubunda ise 1.75 idi ve bu farklılık istatistiksel olarak anlamlıydı p=0.001 . Ortalama TLO değeri NP grubunda 120.79, kontrol grubunda ise 109.84 idi fakat bu farklılık istatistiksel olarak anlamlı değildi p=0.073 .Sonuç: Nazal polipli hastalarda kolay uygulanabilen ve düşük maliyetli testler ile elde edilen NLO değeri yeni bir belirteç olarak kullanılabilir. Trombosit lenfosit oranı değeri için ise daha geniş hasta serili yeni çalışmalara ihtiyaç vardır

Anahtar Kelimeler:

İnflamasyon, lenfosit, nazal polip, nötrofil, trombosit

New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Objectives: This study aims to investigate the correlations between nasal polyposis NP and NP density with neutrophil to lymphocyte ratio NLR and platelet to lymphocyte ratio PLR . Patients and Methods: The study included 105 patients 72 males, 33 females; mean age 41.33±12.85 years; range 16 to 63 years diagnosed as NP NP group and 83 healthy individuals 54 males, 29 females; mean age 44.01±8.50 years; range 18 to 62 years control group . Nasal polyposis density score was calculated with preoperative Lund-Mackay computed tomography grading system. Neutrophil to lymphocyte and PLR ratio values of NP and control groups were calculated and statistically compared. Neutrophil to lymphocyte and PLR values were statistically compared in terms of NP density in the NP group. Results: Mean NLR value was 2.26 in the NP group and 1.75 in the control group with a statistically significant difference p=0.001 . Mean PLR value was 120.79 in the NP group and 109.84 in the control group with a statistically insignificant difference p=0.073 . Conclusion: Neutrophil to lymphocyte ratio value may be used as a novel marker that is easily administered in patients with nasal polyps and obtained with low-cost tests. New studies with larger patient series are needed for the value of PLR.

Keywords:

Inflammation, lymphocyte, nasal polyposis, neutrophil, platelet,

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