Gebelikte koku fonksiyon değişiminin değerlendirilmesi

Amaç: Bu çalışmada farklı trimesterdeki gebe kadınlar ve gebe olmayan kadınlar arasında koku fonksiyon değişimleri karşılaştırıldı.Hastalar ve Yöntemler: Otuz beş sağlıklı gebe kadın ile 14 sağlıklı gebe olmayan kadın çalışmaya dahil edildi. Gönüllü gebe kadınlar ilk trimester, ikinci trimester ve üçüncü trimester olmak üzere üç alt gruba ayrıldı. Tüm gönüllülere koku şişe test bataryası ile koku testi yapıldı. Testin içeriği Sniffin stick ile uyumlu olup, koku eşiği OT , koku ayrımcılık OD ve koku tanımlama OI olarak üç ayrıntılı koku fonksiyon testlerinden oluşmaktaydı. Bu üç testin sonucu TDI skoru olarak belirtildi.Bulgular: İlk trimesterdeki gebe kadınların TDI skorunda ve test skorlarında, diğer trimester gebeler ve gebe olmayan kadınlara kıyasla, istatistiksel olarak anlamlı bir azalma gözlendi p0.05 .Sonuç: Gebelik sürecinde kadınlarda koku fonksiyonlarında değişiklik izlenmektedir. Özellikle ilk trimesterde koku duyarlılığında oluşan azalma, gebeliğin sonlarına doğru normal skorlara ulaşmaktadır

Evaluation of smell function changes in pregnancy

Objectives: This study aims to compare the olfactory function changes among pregnant women in varying trimesters and non-pregnant women. Patients and Methods: Thirty-five healthy pregnant women and 14 non-pregnant women were included in the study. Volunteer pregnant women were divided into three subgroups including the first trimester, second trimester, and third trimester. All volunteers were tested with the smell bottle test battery. The content of the test was consistent with the Sniffin’ sticks including three detailed olfactory function tests, namely olfactory threshold OT , olfactory discrimination OD , and olfactory identification OI . Total results of these three tests were defined as TDI scores. Results: TDI score and test scores of the pregnant women in the first trimester statistically significantly decreased compared to pregnant women in other trimesters and non-pregnant women p<0.05 . Pregnant women in the second and third trimesters had similar olfactory function scores to the non-pregnant women p>0.05 . Conclusion: The olfactory function changes are observed in women during pregnancy. In particular, decreased smell sensitivity in the first trimester returns to normal scores towards the end of pregnancy.

___

  • Cameron EL. Pregnancy and olfaction: a review. Front Psychol 2014;5:67.
  • Ochsenbein-Kölble N, von Mering R, Zimmermann R, Hummel T. Changes in olfactory function in pregnancy and postpartum. Int J Gynaecol Obstet 2007;97:10-4.
  • Kölble N, Hummel T, von Mering R, Huch A, Huch R. Gustatory and olfactory function in the first trimester of pregnancy. Eur J Obstet Gynecol Reprod Biol 2001;99:179-83.
  • Simsek G, Bayar Muluk N, Arikan OK, Ozcan Dag Z, Simsek Y, Dag E. Marked changes in olfactory perception during early pregnancy: a prospective case-control study. Eur Arch Otorhinolaryngol 2015;272:627-30.
  • Mackay-Sim A, Grant L, Owen C, Chant D, Silburn P. Australian norms for a quantitative olfactory function test. J Clin Neurosci 2004;11:874-9.
  • Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984;94:176-8.
  • Yücepur C, Ozücer B, Değirmenci N, Yıldırım Y, Veyseller B, Ozturan O. University of Pennsylvania smell identification test: application to Turkish population. Kulak Burun Bogaz Ihtis Derg 2012;22:77-80.
  • Gül A, Akdağ M, Özkurt FE, Yilmaz B, Şengül E, Bakir S, et al. Cultural adaptation of an olfactory test: the odour in bottle test. [corrected]. Rhinology 2014;52:172-7.
  • Cantoni P, Hudson R, Distel H, Laska M. Changes in olfactory perception and dietary habits in the course of pregnancy: a questionnaire study. Chem Senses 1999;24:58
  • Cameron EL. Measures of human olfactory perception during pregnancy. Chem Senses 2007;32:775-82.
  • Nordin S, Broman DA, Olofsson JK, Wulff M. A longitudinal descriptive study of self-reported abnormal smell and taste perception in pregnant women. Chem Senses 2004;29:391-402.
  • Savović S, Nincić D, Lemajić S, Pilija V, Mandić A, Rajović J, et al. Olfactory perception in women with physiologically altered hormonal status (during pregnancy and menopause. Med Pregl 2002;55:380-3. [Abstract]
  • Laska M, Koch B, Heid B, Hudson R. Failure to demonstrate systematic changes in olfactory perception in the course of pregnancy: a longitudinal study. Chem Senses 1996;21:567-71.
  • Hook EB. Dietary cravings and aversions during pregnancy. Am J Clin Nutr 1978;31:1355-62.
  • Profet M. Pregnancy sickness as adaptation: a deterrent to maternal ingestion of teratogens In: Barkow JH, Cosmides L, Tooby J, editors. The adapted mind: evolutionary psychology and the generation of culture. New York: Oxford University Press; 1992. p. 327-66.
  • Kamath V, Turetsky BI, Moberg PJ. Identification of pleasant, neutral, and unpleasant odors in schizophrenia. Psychiatry Res 2011;187:30-5.