Yavuz Fuat YILMAZ, Filiz AKBIYIK, Ümit TUNÇEL, Adnan ÜNAL

Larenks karsinomlu hastalarda lipid peroksidasyonu ve antioksidan seviyeleri

Amaç: Serbest oksijen radikalleri SOR kanser patogenezinde önemli rol oynamaktadır. Bu çalışmadalarengeal kanser dokusunda lipid peroksidasyonu veSOR seviyeleri araştırıldı.Hastalar ve Yöntemler: Larenks skuamöz hücrelikarsinomlu 30 hastada larengeal tümörlü ve tümörsüz dokuda glutatyon GSH ve malondialdehit MDA düzeyleri ve lipid peroksidasyonu değerlerikarşılaştırıldı.Bulgular: Glutatyon seviyesi kanserli dokuda belirgin olarak düşük bulundu p

Anahtar Kelimeler:

Antioksidan/metabolizma, skuamöz hücreli kanser, serbest radikal.

Lipid peroxidation and antioxidant levels in patients with laryngeal carcinoma

Objectives: Reactive oxygen species ROS play an important role in the pathogenesis of cancer. The aim of this study was to investigate the extent of lipid peroxidation and ROS in laryngeal cancer tissues.Patients and Methods: We determined glutathione GSH and malondialdehyde MDA activities as markers of lipid peroxidation in laryngeal tumor spec- imens and tumor-free adjacent tissues of 30 patients with squamous celi carcinoma.Results: Compared to the tumor-free specimens, the level of GSH was significantly low p0.05 .Conclusions: Decreased antioxidant capacity of laryngeal cancer tissues results in elevation of free oxygen radicals and increased lipid peroxida- tion. Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.

Keywords:

Antioxidants/metabolism carcinoma, squamous celi, free radicals,

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