Turgut KARLIDAĞ, İrfan KAYGUSUZ, Üzeyir GÖK, Şinasi YALÇIN, Erol KELEŞ, Levent ÖZTÜRK

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Efüzyonlu otitis media tedavisinde antibiyotik ile birlikte intranazal steroid kullanımının etkinliği

Amaç : Kronik efüzyonlu otitis media EOM tedavisinde, tekbaflına antibiyotik ve antibiyotik ile birlikte topikal intranazalbudesonid kullanımının etkinliği arafltırıldı.Hastalar ve Yöntemler: Çalıflmaya EOM tanısı almıfl,yaflları 2-12 arasında değiflen 62 hasta alındı. Hastalarrastgele üç gruba ayrıldı. Bir gruba antibiyotik 20 hasta,ampisilin/sulbaktam, 25 mg/kg , bir gruba antibiyotik ilebirlikte intranazal budesonid 20 hasta, 200 mcg/gün verilirken, kontrol grubu 22 hasta tedavisiz izlendi. Hastalarda ve ailelerinde alerji, sık üst solunum yolu enfeksiyonu geçirme, pasif sigara içiciliği, düflük doğum ağırlığı vekrefle gitme hikayesi sorgulandı. Kronik EOM tanısı konduğu andaki ve tedavinin dördüncü ve sekizinci haftalarındaki otoskopik muayene ve timpanogram sonuçları değ e r l e n d i r i l di.Bu l g u l a r : Sekiz haftalık tedavi sonrasında, her iki grubunotoskopik muayene ve timpanogram bulgularında kontrolgrubuna göre anlamlı düzelme görüldü p0.05 .Sonuç: Antibiyotik tedavisi ile birlikte topikal intranazal steroid kullanımının EOM tedavisindeki etkinliği daha geniflhasta serileriyle arafltırılmalıdır
Anahtar Kelimeler:

Uygulama, inhalasyon, ampisilin/terapötik kullanım, çocuk, ilaç tedavisi, kombinasyon, orta kulak ventilasyonu, efüzyonlu otitis media/ilaç tedavisi, pregnenedion/terapötik kullanım, steroid/terapötik kullanım, sulbaktam

The efficacy of combining antibiotic treatment with topical intranasal steroid administration in the treatment of chronic otitis media with effusion

Objectives: We evaluated the efficacy of antibiotic treatment with or vvithout topical administration of intranasal budesonide in chronic otitis media with effusion OME .Patients and Methods: The study included 62 patients age range2to 12years with chronic OME. The patients were ran- domly assigned to three groups, namely, antibiotic treatment 20 patients, ampicillin/sulbactam, 25 mg/kg/daily , antibiotic treatment combined with intranasal budesonide 20 patients, 200 mg/daily , and no treatment 22 patients . Ali patients and families were questioned regarding the presence of allergy, frequent upper respiratory tract infections, passive smoking, low birth weight, and pre-school nursery attendance.Otoscopic examination findings and the results of tym- panograms obtained at the time of diagnosis, and at the end of four and eight weeks of treatment were evaluated.Results: At the end of eight weeks, significant improvement in tympanograms and otoscopic findings was obtained in both groups when compared with the control group p<0.05 .Resolution rates were 24% 9/37 ears , 39% 14/36 , and %5 2/40 with antibiotic, budesonide, and no treatment groups, respectively. Although budesonide treatment was associated with a higher rate of resolution of effusion compared to that of antibiotic alone, this did not reach significance p>0.05 .Conclusion: Further studies with larger patient series are required to better evaluate the efficacy of antibiotic treatment and topical intranasal steroid administration in chronic OME.
Keywords:

Administration, inhalation, ampicillin/therapeutic use, child, drug therapy, combination, middle ear ventilation, otitis media with effusion/drug therapy, pregnenediones/therapeutic use, steroids/therapeutic use, sulbactam,

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The Turkish Journal of Ear Nose and Throat-Cover
  • ISSN: 2602-4837
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 1991
  • Yayıncı: İstanbul Üniversitesi
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