Açık supraglottik larenjektomide preepiglottik alan invazyonunun servikal lenf nodu metastazları üzerine etkisinin gözden geçirilmesi
Amaç: Bu çalışmada preepiglottik alan PEA invazyonu varlığı ve servikal nod metastazı arasındaki ilişki ve bunların hastalıksız sağkalım üzerindeki etkisi değerlendirildi.Hastalar ve Yöntemler: Bu retrospektif kohort çalışmaya iki taraflı boyun diseksiyonu ile açık supraglottik larenjektomi geçiren 49 hasta 45 erkek, 4 kadın; ort. yaş 65 yıl; dağılım 49-87 yıl dahil edildi. Çalışma Ocak 2007 - Ocak 2016 tarihleri arasında yapıldı. Geçmiş bilgisi hastaların dosyalarından edinildi. Toplanan veri PEA invazyonu ve diğer olası prognostik faktörler arasındaki ilişkiyi değerlendirmek için kullanıldı.Bulgular: Preepiglottik alan invazyonu ve aynı taraf nod metastazı arasında istatistiksel olarak anlamlı bir ilişki vardı p=0.001 . Preepiglottik alan invazyonu olmayan hastalarda hastalıksız sağkalım oranı anlamlı olarak daha yüksekti p=0.033 , fakat nod metastazı olanlarda anlamlı ilişki görülmedi.Sonuç: Açık supraglottik parsiyel larenjektomi erken ve seçilmiş ileri evre supraglottik karsinomlu hastalarda kullanılabilecek, onkolojik olarak güvenilir bir işlemdir. Preepiglottik alan invazyonu kötü prognoza yol açan önemli bir risk faktörü olduğundan, tedaviden önce farklı görüntüleme yöntemleri ile titizlikle değerlendirilmelidir
Anahtar Kelimeler:
Servikal lenf nodu metastazı, preepiglottik alan invazyonu, supraglottik larenjektomi, sağkalım
The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited
Objectives: This study aims to evaluate the relationship between presence of preepiglottic space PES invasion and cervical nodal metastasis and their impact on disease free survival. Patients and Methods: This retrospective cohort study included 49 patients 45 males, 4 females; mean age 65 years; range 49 to 87 years who underwent open supraglottic laryngectomy with bilateral neck dissection. The study was conducted between January 2007 and January 2016. The background information was retrieved from patients’ files. The collected data were used to assess the association between PES invasion and other possible prognostic factors. Results: There was a statistically significant relationship between PES invasion and ipsilateral nodal metastasis p=0.001 . Disease free survival rate was significantly higher in patients with no PES invasion p=0.033 but not in those with nodal metastasis. Conclusion: Open supraglottic partial laryngectomy is an oncologically safe procedure that can be used in patients with early and selected advanced stage supraglottic carcinoma. Since PES invasion is a significant risk factor that causes poor prognosis, it should be rigorously evaluated via different imaging modalities before treatment.
Keywords:
Cervical lymph node metastasis, preepiglottic space invasion, supraglottic laryngectomy, survival,
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- ISSN: 2602-4837
- Yayın Aralığı: Yılda 4 Sayı
- Başlangıç: 1991
- Yayıncı: İstanbul Üniversitesi