Prophylactic and therapeutic parotidectomy for secondary neoplasms of the parotid gland

Prophylactic and therapeutic parotidectomy for secondary neoplasms of the parotid gland

ABSTRACTObjectives: The aim of this study was to review the demographic and clinicopathological findings of thepatients who underwent prophylactic or therapeutic parotidectomy due to the secondary neoplasm of the parotidgland (SNP), the outcomes of the patients with SNP and to provide a perspective to the parotid and neckapproach in head and neck skin cancer cases.Methods: The clinical data of 178 patients who underwent parotidectomydue to neoplasm in the Departmentof Otorhinolaryngology, Head and Neck Surgery of a tertiary referral center from 2012 to 2017 were reviewed.Results: Among 178 patients, twenty-two (12.4%) patients were found to underwentprophylactic or therapeuticparotidectomy due to SNP. Six of these patients had pathologically positive parotid metastases (therapeuticparotidectomy). The median age of six patients was 67 years (ranging from 2 to 83 years). Five patients weremale and one was female. The most common indication of parotidectomy (prophylactic and therapeutic) andpathology of parotid mass due to SNP and Cutaneous Squamous Cell Carcinoma (SCC) (36.3% and 50%,respectively).Conclusions: Owing to rapidly progressive feature and high morbidity, close observation of parotid in case ofmetastasis is crucial for recurrent SCC of the face and scalp.

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  • 1. Nuyens M, Schupbach J, Stauffer E, Zbaren P. Metastatic disease to the parotid gland. Otolaryngol Head Neck Surg 2006;135:844-8.
  • 2. D’Souza J, Clark J. Management of the neck in metastatic cutaneous squamous cell carcinoma of the head and neck. Curr Opin Otolaryngol Head Neck Surg 2011;19:99-105.
  • 3. Lukšić I, Virag M, Manojlović S, Macan D. Salivary gland tumours: 25 years of experience from a single institution in Croatia. J Craniomaxillofac Surg 2012;40:e75-81.
  • 4. Barnes L, Eveson JW, Reichart P, Sidransky D. (Eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press: Lyon, 2005.
  • 5. Franzen AM, Günzel T, Lieder A. Parotid gland metastasesof distant primary tumours: a diagnostic challenge. Auris Nasus Larynx 2015;29:187-91.
  • 6. Pomar Blanco P, Martín Villares C, San Román Carbajo J, Tapia Risueño M, Fernández Pello M. [Metastasis to the parotid gland]. Acta Otorrinolaryngol Esp 2006;57:47-50. [Article in Spanish]
  • 7. Rouviere H. Anatomy of the Human Lymphatic System (Tobias JM, translator.) Ann Arbor, Edward Brothers, 1938.
  • 8. Schroeder WA, Stahr WD. Malignant neoplastic disease of the parotid lymph nodes. Laryngoscope 1998;108:1514-9.
  • 9. Zbaren P, Schar C, Hotz MA, Loosli H. Value of fine-needle aspiration cytology of parotid gland masses. Laryngoscope 2001;111:1989-92.
  • 10. Lydiatt WM, Patel SG, O'Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and neck cancers - major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67:122-37.
  • 11. Stratigos A, Garbe C, Lebbe C, Malvehy J, Del Marmol V, Pehamberger H, et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer 2015;51:1989-2007.
  • 12. Jambusaria-Pahlajani A, Miller CJ, Quon H, Smith N, Klein RQ, Schmults CD. Surgical monotherapy versus surgery plus adjuvant radiotherapy in high-risk cutaneous squamous cell carcinoma: a systematic review of outcomes. Dermatol Surg 2009;35:574-85.
  • 13. Wong WK, Morton RP. Elective management of cervical and parotid lymph nodes in stage N0 cutaneous squamous cell carcinoma of the head and neck: a decision analysis. Eur Arch Otorhinolaryngol 2014;271:3011-9.
  • 14. Skulsky SL, O'Sullivan B, McArdle O, Leader M, Roche M, Conlon PJ, et al. Review of high-risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines in Oncology. Head Neck 2017;39,578-94.
  • 15. Andruchow JL, Veness MJ, Morgan GJ, Gao K, Clifford A, Shannon KF, et al. Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a mulitcenter study of treatment outcomes. Cancer 2006;106:1078- 83.
  • 16. Kadakia S, Saman M, Gordin E, Marra D, Ducic Y. The role of parotidectomy in the treatment of auricular squamous cell carcinoma. Otolaryngol Head Neck Surg 2015;152:1048-52.
  • 17. Haksever M, Akduman D, Demir M, Aslan S, Yanılmaz M, Solmaz F. The treatment of neck and parotid gland in cutaneous squamous cell carcinoma of face and forehead and the review of literature. Ann Med Surg 2015;4:48-52.
  • 18. Hoch S, Franke N, Katabi N, Werner JA, Teymoortash A. The value of elective parotidectomy in advanced squamous cell carcinoma of the skin of the head. Anticancer Res 2014;34:2433- 6.
  • 19. Osborne RF, Shaw T, Zandifar H, Kraus D. Elective parotidectomy in the management of advanced auricular malignancies. Laryngoscope 2008;118:2139-45.
  • 20. Durbec M, Couloigner V, Tronche S, Albert S, Kanitakis J, Ltaief Boudrigua A, et al. Guidelines of the French Society of Otorhinolaryngology (SFORL), short version. Extension assessment and principles of resection in cutaneous head and neck tumors. European Ann Otorhinolaryngol Head Neck Dis 2014;131:375-83.
  • 21. O’Brien CJ, McNeil ED, McMahon JD, Pathak I, Lauer CS. Incidence of cervical node involvement in metastatic cutaneous malignancy involving the parotid gland. Head Neck 2001;23:744-8.
  • 22. Taylor BW, Brant TA, Mendenhall NP, Mendenhall WM, Cassisi NJ, Stringer SP, et al. Carcinoma of the skin metastatic to parotid area lymph nodes. Head Neck 1991;13:427-33.
  • 23. Bron LP, Traynor SJ, McNeil EB, O’Brien CJ. Primary and metastatic cancer of the parotid: comparison of clinical behaviour in 232 cases. Layngoscope 2003;113:1070-5.
  • 24. Chua MS, Veness MJ, Morgan G, Shakespeare T, Hehir A, Gebski V, et al. Parotid lymph node metastasis from cutaneous squamous-cell carcinomas: treatment outcome and prognostic factors following surgery and adjuvant radiotherapy. Australas Radiol 2002;46:174-9.
  • 25.PastoreA, Ciorba A, Soliani M, Di Laora A, Valpiani G, Bianchini C, et al. Secondary malignant tumors of the parotid gland: not a secondary problem. J BUON 2017;22:513-8.
  • 26. Pisani P, Krengli M, Ramponi A, Guglielmetti R, Pia F. Metastases to parotid gland from cancers from upper airway and digestive tract. Br J Oral Maxillofacial Surg 1998;36:54-7.
  • 27. Harada H, Omura K. Metastasis of oral cancer to the parotid node. Eur J Surg Oncol 2009;35:890-4.
  • 28. Zhang C, Cohen JM, Cangiarella JF, Waisman J, McKenna BJ, Chhieng DC. Fine-needle aspiration of secondary neoplasms involving the salivary glands. Am J Clin Pathol 2000;113:21-8.
  • 29. Gregoire V, Ang K, Budach W. Delineation of the neck node levels for head and neck tumors: a 2013 update. DAHANCA, EORTC, HKNPCSG, NCIC CTG, NCRI, RTOG, TROG consensus guidelines. Radiother Oncol 2014;110:172-81.
  • 30. Dong XR, Zhang T, Fan L, Zhang S, Wu G. Parotid gland metastasis of nasopharyngeal carcinoma: case report and review of the literature. J Int Med Res 2009;37:1994-9.
  • 31. Yeung KW, Chiang PT, Chang CY, Yuan BC. A parotid gland mass as an initial metastatic manifestation of nasopharyngeal carcinoma. J Cancer Res Pract 2018;5:123-6.
  • 32. Wang S, Lou J, Zhang S, Guo L, Wang K, Ge M. Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study. World J Surg Oncol 2015;13:1.
  • 33. Xu Y, Chen X, Zhang M, Xiao Y, Zong J, Guo Q, et al. Prognostic effect of parotid area lymph node metastases after preliminary diagnosis of nasopharyngeal carcinoma: a propensity score matching study. Cancer Med 2017;6:2213-21.
  • 34. Dequanter D, Lothaire P, Andry G. Secondary malignant tumors of the parotid. Ann Otolaryngol Chir Cervicofac 2005;122:18-20.