Ali Dalgıç, Güner Menekşe, Ahmet Deniz Belen, Özhan Merzuk Uçkun, Denizhan Divanlıoğlu, Rıfat Akdağ

Dehydrated human amnion/chorion membrane allograft for preventing epidural fibrosis after laminectomy: an experimental rat model

Objectives: Post-laminectomy syndrome due to epidural fibrosis (EF) is a common cause of persistent lowback pain after lumbar spinal surgery and is challenging for both surgeons and patients. The current experimental study aimed to investigate the effect of dehydrated human amnion/chorion membrane (dHACM)allograft for preventing EF formation following lumbar laminectomy.Methods: Sixteen Sprague–Dawley rats equally divided into two groups underwent lumbar laminectomy.Group A, the control group, underwent lumbar laminectomy with standard closure. Group B, the experimentalgroup, additionally received epidural dHACM allografts during the procedure. After 45 days of follow-up, therats were sacrificed, and the harvested tissues were histopathologically evaluated for EF.Results: Compared with Group A, Group B showed significantly less EF generation (p < 0.001), implyingthat dHACM allografts effectively prevent EF.Conclusions: This study demonstrated that dHACM can effectively reduce EF formation after spinallaminectomy in rats.

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