C-reactive protein to albumin ratio in Behçet’s disease

Objectives: This study aims to evaluate the relationship between C-reactive protein (CRP)/albumin ratio (CAR) and other hematological parameters in Behçet's disease (BD). Methods: A total of 200 participants (100 BD patients and 100 healthy control) were recruited from the rheumatology outpatient clinic in this cross-sectional study. Laboratory tests were conducted to measure complete blood count, erythrocyte sedimentation rate (ESR), CRP, albumin, CAR, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR). Laboratory findings of BD patients and healthy controls were compared and evaluated. BD Activity scores (Behçet's Disease Current Activity Form [BDCAF]) were calculated. Results: In the BD group, there were 42 male and 58 female participants with a mean age of 42.49 ± 13.15 years and in the healthy control group, 44 male and 56 female participants with a mean age of 44.90 ± 10.98 years. NLR, CRP, ESR and CAR values were significantly higher in patient group than in the healthy controls (p < 0.05). BDCAF score varied between 0 and 4 with a mean of 1.55 ± 0.64. A statistically significant correlation was observed between BDCAF and CRP, ESR and CAR (p < 0.0001). Conclusions: In this study, a significant correlation was found between CAR and BDCAF, NLR, CRP, albumin and ESR. CAR can be useful in the diagnosis and following of BD patients.

Keywords:

Albumin, Behçet’s disease, C-reactive protein C-reactive protein/albumin ratio,

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1. Yazici Y, Hatemi G, Bodaghi B, Cheon JH, Suzuki N, Ambrose N, et al. Behçet syndrome. Nat Rev Dis Primers 2021;7:67.
2. Bettiol A, Prisco D, Emmi G. Behçet: the syndrome. Rheumatology 2020;59(Suppl_3):101-7.
3. Hou CC, Guan JL. Risk factors of disease activity in patients with Behçet’s syndrome. Clinical Rheumatology 2021;40:1465-71.
4. Enginar AU, Kacar C. Neutrophil-lymphocyte and platelet-lymphocyte rate and their seasonal differences in ankylosing spondylitis and rheumatoid arthritis patients using anti-TNF medication. Bratisl Lek Listy 2019;120:586-92.
5. Hammad M, Shehata OZ, Abdel-Latif SM, Mohiey El-Din AM. Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in Behcet's disease: which and when to use? Clin Rheumatol 2018;37:2811-7.
6. Lee YH, Song GG. Neutrophil-to-lymphocyte ratio, mean platelet volume and platelet-to-lymphocyte ratio in Behcet's disease and their correlation with disease activity: a meta-analysis. Int J Rheum Dis 2018;21:2180-7.
7. Balkarli A, Kucuk A, Babur H, Erbasan F. Neutrophil/lymphocyte ratio and mean platelet volume in Behçet’s disease. Eur Rev Med Pharmacol Sci 2016;20:3045-50.
8. Jiang Y, Zang M, Li S. Serum PLR and LMR in Behcet's disease: can they show the disease activity? Medicine (Baltimore) 2017;96:e6981
9. Zhong Z, Huang Y, Liu Y, Chen J, Lie M, Huang Q, et al. Correlation between C-reactive protein to albumin ratio and disease activity in patients with axial spondyloarthritis. Dis Markers 2021;2021:6642486
10. Moon JS, Ahn SS, Park YB, Lee SK, Lee SW. C-reactive protein to serum albumin ratio is an independent predictor of all-cause mortality in patients with ANCA-associated vasculitis. Yonsei Med J 2018;59:865-71.
11. Yang WM, Zhang WH, Ying HQ, Xu YM, Zhang J, Min QH, et al. Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: albumin to fibrinogen ratio and C-reactive protein to albumin ratio. Int Immunopharmacol 2018;62:293-8.
12. Cao X, Zhao M, Li H, Xu D, Li M, Zhang X, et al. Three new inflammatory markers C reactive protein to albumin ratio, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio correlated with relapsing polychondritis disease activity index. Clin Rheumatol 2021;40:4685-91.
13. Slouma M, Rahmouni S, Dhahri R, Gharsallah I, Metouı L, Louzir B. Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, C-reactive protein to albumin ratio, and albumin to fibrinogen ratio in axial spondyloarthritis: a monocentric study. Curr Rheumatol Rev 2021;17:312-7.
14. Liu X, Wang L, Zhou K, Shao S, Hua Y, Wu M, et al. Predictive value of C-reactive protein to albumin ratio as a biomarker for initial and repeated intravenous immunoglobulin resistance in a large cohort of Kawasaki disease patients:a prospective cohort study. Pediatr Rheumatol Online J 2021;19:24.
15. Kim M, Park YG, Park YH. C-reactive protein/albumin ratio as an indicator of disease activity in Behçet’s disease and human leukocyte antigen-B27-associated uveitis. Graefes Arch Clin Exp Ophthalmol 2021;259:1985-92.
16. Bozkurt E, Muhafiz E, Sengul D, Uçak T, Atum M. Can the CRP/albumin ratio be used as a new indicator of activation in patients with uveitis? Ocul Immunol Inflamm 2021;29:1017-22.
17. International Study Group for Behçet’s Disease. Criteria for diagnosis of Behçet’s disease. Lancet 1990;335:1078-80.
18. Lawton G, Bhakta BB, Chamberlain MA, Tennant A. The Behcet’s disease activity index. Rheumatology (Oxford) 2004;43:73-8.
19. Hamuryudan V, Fresko I, Direskeneli H, Tenant MJ, Yurdakul S, Akoglu T, et al. Evaluation of the Turkish translation of a disease activity form for Behcet’s syndrome. Rheumatology (Oxford) 1999;38:734-6.
20. Hatemi G, Esatoglu SN, Yazici Y. Biomarkers in vasculitis. Curr Opin Rheumatol 2018;30:30-5.
21. Melikoglu M, Topkarci Z. Is there a relation between clinical disease activity and acute phase response in Behcet’s disease? Int J Dermatol 2013;53:250-4.

ISSN: 2149-3189
Yayın Aralığı: Yılda 6 Sayı
Başlangıç: 2015
Yayıncı: Prusa Medikal Yayıncılık Limited Şirketi

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