The study reports comparative bioeconomic efficiency of different cotton based intercropping systems using high yielding cotton cv. NIAB 78 of Pakistan in 80 cm spaced rows and 120/40 cm spaced rows with cowpea and sorghum as intercrops. Land equivalent ratio showed 32-46 % advantage over sole cropping in both planting patterns. Values of Area time equivalent ratio showed 5-13 % advantage in cotton+cowpea and 9-23 % disadvantage in cotton+sorghum intercropping. Agressivity and competitive ratio showed dominancy of cotton over intercrops while intercrops were more dominant than cotton in actual yield loss values. Values of AYL showed an advantage of 32.1 % to 116.3 % from intercropping due to recovery made by intercrops. Intercropping advantage values showed intercropping disadvantage (-3.865 to -151.035) from intercropping due to price diffference of the component crop which meant that intercrops failed to compensate. Monetary advantage index values were also positive showing a definite yield advantage. Intercropping with cowpea reduced the yield of cotton, however, it seemed more appropriate for intercropping with cotton in both 80 cm and 120/40 cm spaced rows.. 120/40 cm spaced rows spacing seemed better compared to single row spacing for easy handling of intercrops and sole cotton, therefore, it is recommended for mechanical farming in Pakistan.