Musluh HAKSEVEN, Murat KAPAN, Ulaş ALABALIK, Gökhan AVŞAR

SİLDENAFİL SİTRAT VE DEKSPANTENOLÜN YARA İYİLEŞMESİ ÜZERİNDEKİ ETKİLERİNİN KARŞILAŞTIRILMASI: DENEYSEL ÇALIŞMA

Amaç Yara iyileşmesi cerrahide yüksek morbiditeye neden olabilen ciddi bir problemdir. Yara iyileşmesini hızlandırmak, nekrozu veya iskemiyi önlemek için değişik farmakolojik ajanlar çalışılmış ve halen yaygın olarak çalışılmaya devam etmektedir. Yara iyileşmesinde klinik pratikte topikal dekspantenolün geniş kulanım alanları mevcuttur. Topikal dekspantenol hem yara bakımında hem de dermatolojik hastalıkların tedavisinde kullanılmaktadır. Bu çalışmamızda, ratlarda oluşturulan deneysel yara modelinde lokal sildenafil sitrat ve topikal dekspantenol uygulamalarının etkilerinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntem Çalışmada 200–250 gram arasında değişen 30 Adet Wistar Albino dişi rat kullanıldı. Hayvanlar üç gruba ayrıldı. Deney hayvanlarının anestezisini takiben sırt orta kesimlerine 2 cm uzunluğunda tam kat kalınlıkta deri defekti oluşturuldu. Yara pansumanında tüm hayvanların yaraları steril % 0.9 NaCl solüsyonu ile yıkandıktan sonra kontrol grubu olduğu gibi bırakılırken, irigasyon sonrası 2. gruba %5’lik dekspantenol krem, 3. gruba % 10’luk sildenafil krem uygulandı. Ratlarda yara boyutları 3., 5., 7., 10., 14. ve 21. günlerde ölçülerek kaydedildi ve 21. gün tüm ratların sırt kısımlarından insizyon hattını içerecek şekilde tam kat deri çıkarılarak histolojik incelemeye alındı. Bulgular Tüm gruplara genel olarak bakıldığında günlere göre yara boyutlarındaki küçülme ve histopatolojik bulgular açısından istatiksel olarak anlamlı fark saptanmadı. Sonuç Sildenafil sitratın yara boyutunda önemli bir azalmaya yol açtığı için yara iyileşmesi için topikal bir krem olarak kullanılabileceğine inanıyoruz.

COMPARING THE EFFECTS OF SILDENAFIL CITRATE AND DEXPANTHENOL ON WOUND HEALING: AN EXPERIMENTAL STUDY

Objective Wound healing is a serious problem that causes high morbidity. Different pharmacological agents have been studied to accelerate wound healing and to prevent necrosis and ischemia, and still continue to work. Topical dexpanthenol is widely used in both ağırlığınwound healing and various dermatological diseases. The aim of this study was to compare the effects of topical sildenafil citrate and topical dexpanthenol on wound healing in rats. Material and Method A total of 30 female Wistar Albino rats, weighing 200- 250 gr, were used in the study. Rats were divided into 3 groups. A linear 2 cm full-thickness incision was made in the rat’s skin of the back. Steril saline irrigation was applied to all animals in the control group. Dexpanthenol was administered locally to the wounds of the rats in the second group, and 10% sildenafil citrate in the third group. Wound dimensions were measured on the 3rd, 5th, 7th, 10th, 14th, and 21st days. The full-thickness skin, including the incision, were removed for histopathological examination on the 21st days. Results We believe that sildenafil citrate can be used as a topical cream for wound healing, as it leads to significant reduction in wound size. Conclusion Although there was no statistically significant difference, we observed that the wound healing was better in the group where sildenafil citrate was applied locally on the wound.

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