Süleyman KUTLUHAN, FATİH GÜLTEKİN, Memduh KERMAN, Hasan Rifat KOYUNCUOĞLU, Galip AKHAN

Protective role of EGb 761 on cerebral ischemic damage, comparison with mannitol and U74389F

Amaç: Mannitol, EGb 761 (Ginkgo biloba extract) ve U74389F (lazaroid) .in antiödematöz etksini karşılaştırmak amacıyla bu çalışma dizayn edildi. Gereç ve yöntem: Herbirinde 10'ar rat olmak üzere 4 grup oluşturuldu. Izotonik NaCl uygulanan kontrol grubu, EGb uygulanan grup, U74389F uygulanan grup ve Mannitol uygulanan grup. Tüm gruplarda bilateral arteria karotis kommunislerin oklüzyonu ile serebral iskemi oluşturuldu. Her gruba ilgili olduğu ilaç uygulandı. Beyinler çıkartılarak beyin su miktarları belirlendi. Bulgular: Beyin su miktarı EGb 761, mannitol, ve U74389F uygulanan gruplarda kontrol grubuna göre anlamlı olarak azaldı (p

Anahtar Kelimeler:

Antioksidanlar, Bitki ekstreleri, Pregnatrienler, Ginkgo biloba, Beyin iskemisi, Mannitol, Sıçan, Wistar

EGb 761'in mannitol ve U74389F ile karşılaştırılmalı olarak serebral iskemi üzerine koruyucu rolü

Aim: We designed an experimental study to compare the antiedematous effect of three different kind drugs which were Mannitol, EGb 761 (Ginkgo biloba extract) and U74389F (lazaroid). Materials and Methods: Forty rats were assigned into four groups (n=10, for each) as following: Control (saline) group, EGb 761 treatment group, U74389F treatment group, and mannitol treatment group. In all groups, cerebral ischemia was induced by bilateral common carotid artery occlusion. The agents were applied to appropriate groups. The brains were removed and brain water content was determined. Results: The brain water content significantly decreased in EGb 761, mannitol, and U74389F treated groups when compared to control group (p<0.001). On the other hand, the water content was higher in U74389F treated group, comparing with EGb 761 and mannitol groups. Conclusion: These results indicate that EGb 761, U74389F and mannitol are effective treatment agents in the experimental brain ischemia in rats. Among these agents EGb 761 and mannitol showed the best and the same effect.

Keywords:

Antioxidants, Plant Extracts, Pregnatrienes, Ginkgo biloba, Brain Ischemia, Mannitol, Rats, Wistar,

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