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PLATELETTEN ZENGİN FİBRİNİN İYİLEŞME VE REJENERASYON SÜRECİNDEKİ ROLÜ VE ORTOPEDİK CERRAHİDE KULLANIMINA DAİR BİR DERLEME

Plateletten zengin fibrin (PZF) doğal yollardan oluşan bir fibrin bazı ve ikinci-jenerasyon trombosit konsantresidir. Farklı büyüme faktörleri ve sitokinlerin sekresyonu, osteoblast adezyonunu kolaylaştırıcı etkisi ve kollajen protein ekspresyonunun artışı gibi fonksiyonları açısından yara iyileşmesi ve rejenerasyon sürecini tetikleyici potansiyeli büyüktür. PZF kullanımının ortopedik cerrahi alanındaki öneminden hareketle, bu derlemede PZF’nin iyileşme ve rejenerasyondaki rolü ve ortopedik cerrahideki kullanımı sunulmaktadır. Sonuç olarak, PZF klinik araştırmalara yeni bir boyut getiren ve ortopedik cerrahide kullanım alanı açısından geniş potansiyel vaad eden bir tedavi alternatifidir. Daha basit hazırlama protokolü, fizyolojik bir yapıda olmasını sağlayan daha güçlü ve stabil fibrin polimerizasyonu, daha esnek ve iyi fibrin ağını sağlayan doğal yollarla pıhtı oluşumu ve büyüme faktörleri ve sitokinlerin sürekli ve zaman içinde dengeli salınımı ile yara iyileşmesi ve rejenerasyon süreci fizyolojik kriterlerini karşılar görünmektedir.

A REVIEW OF THE ROLE OF PLATELET RICH FIBRIN IN HEALING AND REGENERATIVE PROCESS AND ITS USE IN ORTHOPAEDIC SURGERY

Platelet-rich fibrin (PRF) is a naturally derived fibrin scaffold and second-generation platelet concentrate. It has great potential for promoting wound healing andthe regenerative process via the secretion of different cytokines and growth factors, enhanced osteoblast adhesion, and augmentation of collagen protein expression. Given the significance of the scope of PRF in the field of orthopaedic surgery, this study presents an overview for the role of PRF in the recovery and the regenerative process with emphasis on use in orthopaedic surgery. In conclusion, PRF offers a new dimension for clinical research with expanded range of potential applications in orthopaedic surgery. It seems to have a simpler preparation protocol, a stronger andmore stable fibrin polymerization leading to a physiologic architecture, occurrence of natural clot formation allowing formation of a flexible and fine fibrin networkand a continual and steady release of cytokines and growth factors, mimicking the requirements of the reparative tissue and wound healing processes.

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