Migren patogenezinde oksidatif strese duyarlı TRP kanallarının rolleri

Günümüzde ülkemiz nüfusunun yaklaşık %17'sini etkileyen ve halk arasında yaygınlığı gittikçe artan bir hastalık olan migren tek taraflı baş ağrısı ile karakterizedir. Vücudumuzda fizyolojik şartlarda üretilen oksidan ajanlar ile antioksidan moleküller arasındaki dengenin oksidan ajanlar lehine kayması oksidatif stres durumu olarak ifade edilmektedir ve son yıllarda gerek çevre şartları ve gerekse elektromanyetik alanların artması ile bireylerde oksidatif düzeyleri önemli ölçülerde artmaktadır. Sayısı hızla artan çalışmalarla oksidatif stresin migren patofizyolojisinde de temel rol oynayabileceği iddialı bir şekilde bildirilmiştir. İyon kanalları, hücre membranına gömülü ve hücre canlılığı için gerekli temel moleküllerin alış verişinde görev alan protein yapılı unsurlardır. Oksidatif ajanlar TRP iyon kanallarını uyarabilmekte ve aktivasyon sonucu migren tetikleyicisi nöropeptidlerin salınımıyla ataklar gelişebilmektedir. Bu nedenle bu derlemede oksidatif stresle aktive olabilen TRP iyon kanallarının migren patogenezinde etkinliği vurgulanmaya çalışılmıştır

Role of oxidative stress sensitive TRP channels in pathogenesis of migraine

Migraine a disease, which effects about 17 per cent our country population and spread increasingly among public, characterized with hemicranial head pain. Oxidative stress status, between antioxidant molecules and oxidant agents balance shift to oxidant agents which both produced physiological conditions in our body. Recent years, rapidly growing ambitious studies have been reported that oxidative stress play a basic role also pathophysiology of migraine. Ion channels, built by proteins are embedded in cell membrane and responsible for exchange essential molecules that require for cell viability. Oxidative agents can stimulate TRP ion channels and migraine attacks can occur by releasing migraine trigger neuropeptides result of channel activation. So in this review emphasized that effectiveness of oxidative stress sensitive TRP channels on pathogenesis of migraine

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