Selahattin VURAL, Tuğrul KESİCİOĞLU, İsmail AYDIN

Artmış RDW Değeri ile Kolelitiazis İlişkisi

Amaç: Kırmızı hücre dağılım genişliği (RDW) , kırmızı kan hücrelerinin hacmin değişkenliğini göstermekte olup yakın zamanda yapılan çalışmalarda birçok hastalıkla ilişkili bulunmuştur ve bu hastaların hastalıklarının gidişatını öngörmede belirteç olarak kullanılabileceği gösterilmiştir. Biz de bu çalışmamızda serum RDW değeri ile kolelitiazis hastalığı ve semptomları arasında ilişki olup olmadığını saptamayı amaçladık. Materyal-Metot: Toplam 204 kadın hasta ( 101 kolelitiazis ve 103 kontrol ) çalışmaya dahil edildi. Hastaların demografik özellikleri ve RDW içeren rutin kan sayımı parametreleri kayıt edildi. Kolelitiazis hastaları semptomatik olup olmadıklarına göre iki gruba ayrıldı. Hasta grupları demografik ve laboratuar parametreleri açısından karşılaştırıldı. Bulgular: Gruplar arasında demografik özellikler açısından fark izlenmedi.Çalışma grubumuzda ortalama RDW değeri kolelitiazis grubunda kontrol grubuna göre yüksek bulundu. Subgrup analizinde semptomatik grup ve semptomatik olmayan grup arasında RDW açısından fark bulunamadı. Sonuç: Sonuç olarak çalışmamızda serum RDW değeri ile kolelitiazis hastalığı arasında ilişki saptandı. Fakat kolelitiazis hasalığında RDW değerinin rolü olup olmadığı ve bu basit ve rutin olarak değerlendirilen parametrenin hastalığın prognozunu öngörmede kullanılıp kullanılamayacağına dair gelecekte çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler:

Kırmızı hücre dağılım genişliği, kolelitiazis, enflamasyon

Elevated Level of RDW is Associated with Cholelithiasis

Objective: Red cell distribution width (RDW) ,an index of heterogenity of circulating red blood cell, has recently been found to be associated with multiple diseases and used as a marker to predict outcome in these patients. In the present study we aimed to investigate if RDW value is associated with cholelithiasis and symptoms of the disease.Material- Method: A total of 204 women (101 with cholelithiasis and 103 without the disease ) were included to the study. The demographic and the laboratory data of the routine complete blood cell parameters including RDW values were recorded. Women with cholelithiasis were divided into symptomatic or non-symptomatic group according to presence of biliary colic or pain. The patients were compared in terms of their demographic and laboratory characteristics.Results: Age and BMI were similiar between groups in the study population. In our study population mean RDW value was signifi¬cantly higher in women with cholelithiasis than without disease. However in subgroup analysis there was no significant difference of RDW value between symptomatic group and nonsymptomatic group Conclusion: In conclusion we demonstrated an association between serum RDW level and cholelithiasis in our study but not with disease symptom. However further studies are needed to understand the role of RDW in patients with cholelithiasis and if this simple , inexpensive and routinely reported parameter can be used for prognostic information in this disease.

Keywords:

Red Cell Distribution Width, Cholelithiasis, Inflammation,

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