Ayşe Çağlar Sarılar, Emel Köseoğlu, Çağla Eröz, Gönül Gülmez, Fahri Oğuzkaya, Büşra Sümeyye Arıca Polat

Myastenia Gravis Hastalarında Timektominin Klinik İyileşmeye Etkisi

Amaç: Timektomi, Myastenia Gravis hastalarında klinik iyileşme ve remisyona etkisi en belirgin tedavilerden biridir. Bu çalışmanın asıl amacı timektomiden görülen faydaya etkisi olan faktörleri bulabilmektir. Metod: Fakültemizde Myastenia Gravis’i olan ve timektomi operasyonu olmuş 27 hastanın iki yıllık takiplerindeki bilgileri retrospektif olarak tarandı. Hastaların yaş ve cinsiyet gibi demografik verileri ile timik patolojileri, hastalık tanısı aldıkları zamanı, tanı ile timektomi arasındaki süreleri ve hastalık şiddeti (Osserman sınıflaması) gibi bilgileri kaydedildi. Tüm bu faktörlerin klinik iyileşmeye etkisi olup olmadığı; hastaların klinik durumları, Myastenia Gravis-Günlük Yaşam Aktiviteleri skorları ve aldıkları tedavileri timektomi öncesi ve sonrası olarak iki gruba ayrılıp karşılaştırılarak incelendi. Bulgular: Hastaların %59,3’ü kadın ve yaş ortalamaları 45.9 ±15.2 yıldı. Hastaların %70,4’ünde klinik iyileşme gözlendi. Timektomi öncesi MG-ADL skorlarının ortalaması 6.88±3.02 iken, ikinci yıl takiplerinde MG-ADL skor ortalamaları 5.44±3.78 olarak bulundu ve iki grup arasında anlamlı fark saptandı (p

The Effect of Thymectomy on Clinical Improvement in Patients with Myasthenia Gravis

Background: Thymectomy is a treatment with the most important effect on clinical improvement and remission in Myasthenia Gravis patients. The main purpose of this study is to reveal the factors that effect the benefit of thymectomy. Methods:The data of 27 patients who had Myasthenia Gravis and had thymectomy operation in our faculty were reviewed retrospectively during their 2-year follow-up. Demographic data such as age and gender, thymic pathologies, time of diagnosis, time between diagnosis and thymectomy, and disease severity (Osserman classification) were recorded. Whether all these factors have an effect on clinical improvement; the clinical status of the patients, Myasthenia Gravis- Activities of Daily Living scores and the treatments they received were compared in two groups as before and after thymectomy. Results:59.3% of the patients were female (mean age ±SD: 45,9 ± 15,2 years). Clinical improvement was observed in 70.4% of the patients. When the mean Myasthenia Gravis- Activities of Daily Living scores were compared before and 2 year after thymectomy, a significant difference was found (respectively 6.88±3.02 /5.44±3.78, p

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