This study was conducted to determine the levels of melatonin in the day and night milk of Holstein and Jersey cows. In the study, samples of daytime milk produced from 27 head of Holstein and 27 head of Jersey cows in the first lactation, which were raised in a private dairy cattle enterprise in the Kaşınhanı neighborhood of Meram district of Konya city Turkey, and night milk samples taken from the same cows that were blackened for one (1) week were used. Melatonin levels in milk samples taken from day and night milk were determined separately for Holstein and Jersey cows with the help of Bovine Melatonin (MLT) Elisa Kit. In the study, it was determined that the ratio of melatonin in day and night milk in Holstein cows was 2.912 pg/ml and 11.314 pg/ml, respectively, and the ratio of melatonin in Jersey cows was 2.924 pg/ml and 6.954 pg/ml in the same order. The difference between the melatonin levels of the day and night milk of Holstein and Jersey cows was found to be statistically significant (p
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Asher A, Sbabtay A, Brosh A, Eitam H, Agmon R, Cohen-Zinder M, Zubidat AE, Haim A (2015). "Chrona-functional milk": The differecence between melatonin concentration in night-milk versus day-milk under different illumination conditions. Chronabiol Int., 32:1409-1416.
Bae SM, Jeong J, Jeon HJ, Bang YR, Yoon IY (2016). Effects of melatonin-rich milk on mild insomnia symptoms. Sleep Medicine Research, 7(2): 60-67.
Balch PA (2010). Health and Fitness, boks.google.com.tr/boks?isbn=1583332367, Accession Date: 6.9.2010.
Gürbüz F, Başpınar E, Çamdeviren H, Keskin S (2003). Tekrarlanan Ölçümlü Deneme Düzenlerinin Analizi. Van.
Holzmann VMM, Trentin M, Rego FCA, Filho LFCC, Ludovico A (2019). Melatonin concentration in the milk of cows supplemented with vitamins and milked twice Daily. The Journal Semina Ciencias Agrarias, 40 (5): 2017-2026.
Jainudeen MR, Wahid H, Hafez ESE (2000). Sheep and Goats (Chapter 12), Reproduction in Farm An-imals, Hafez E.S.E and Hafez B. (ed): 172-179.
Liu T, Borjigin J (2006). Relationship between nocturnal serotonin surge and melatonin onset in rodent pineal gland. Journal of Circadian Rythms, 4:12.
Mullins KJ (2010). Night time milking produces milk with extra melatonin, digitaljour-nal.com/article/297161 (SEP 7, 2010), Accession Date: 16.09.2010
Özçelik F, Erdem M, Bolu A, Gülsün M (2013). Melatonin: Genel Özellikleri ve Psikiyatrik Bo-zukluklardaki Rolü (Melatonin: General Features and its Role in Psychiatric Disorders) Psikiyatride Güncel Yaklaşımlar-Current Approaches in Psychi-atry 179-203 doi:10.5455/cap.20130512
Romanini EB, Volpato AM, dos Santos JS, de Santana EHW, de Souza, CHB, Ludovico A (2019). Melatonin concentration in cow's milk and sources of its variation. Journal of Applied Animal Research. 47(1): 140-145.
RStudio https://www.rstudio.com/ Access date: 25.03.2021
Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP (2008). Jet lag: Therapeutic use of melatonin and possible application of melatonin analogs. Travel Medicine and Infectious Disease, (6): 17–28.
Şahin Ö, Akyürek F, Boztepe S, Aytekin İ, Keskin İ (2021). Determination of melatonin differences between day and night milk in dairy cattle. Journal of Agricultural Sciences (Tarim Bilimleri Dergisi) 27 1 – 5 DOI: 10.15832/ankutbd.687769bdalla HA (2012).
Valtonen M, Niskanen L, Kangas A-P, Koskinen T (2005). Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects. Nordic Journal of Psychiatry, 59 (3): 217- 221.