Agricultural production is one of the main factors that have significant on environment. Sustainable agricultural systems combine traditional methods and modern techniques to provide a continuous and economic production by considering natural resources and all the environment components. Using of pesticides and chemical fertilizers in agriculture are main pollutant factors to environment due to negative effects on human health, environment security, soil quality and increased pathogen resistance. Soil fauna includes worm, protozoa, nematode etc. animals. Many of worm species fed by residues such as crops, animal wastes, sewage sludge, industrial refuse etc. mediums while Eisenia fetida (Savigny) is mostly live in organic wastes and known as an accelerator for waste stabilization by decomposition, mineralization, nitrogen transformations and includes various enzyme, vitamins, amino acids, growing regulators which lead to better medium for plant growing as vermiculture. Besides an increasing tendency for using of worm manure and its developing industry, their lifecycle and activities are studied extensively over world while less studied in Turkey especially about importance in sustainable agricultural systems. Present paper reviews using of worm manure to provide sustainable environment systems that is an issue for human health by functional food production and application of environmental friend production systems.