Mustafa Cihan YAVUZ, Cenk Fatih ÇANAKÇI

Kontrol Altında ve Kontrol Altında Olmayan Tip 2 Diyabete SahipKronik Periodontitisli Bireylerde Tükürük, Serum ve GCF VisfatinSeviyelerinin İncelenmesi

Amaç: Bu çalışmanın amacı, metabolik kontrolleri iyi ve kötü diyabetikkronik periodontitisli hastaların ve non-diyabetik kronik periodontitislihastaların DOS, tükürük ve serum örneklerinde visfatin seviyelerininaraştırılmasıdır. Gereç ve Yöntemler: Bu çalışmada her biri 15 katılımcıdan oluşan 5grup oluşturuldu; sistemik sağlıklı ve periodontal olarak sağlıklıbireylerin oluşturduğu grup (DM-P-), sistemik sağlıklı ve kronikperiodontitisli grup (DM-P+), diyabetli ve periodontal olarak sağlıklıgrup (DM+P-) ile diyabetli ve kronik periodontitisli grup (DM+P+),kontrolsüz diyabetli ve kronik periodontitisli grup (uDM+P+). Serum,tükürük ve DOS örneklerinin alınmasını takiben klinik periodontalparametreler kaydedildi. Lokal ve sistemik visfatin, TNF-α ve IL-1β düzeyleri biyokimyasal olarak ölçüldü. Bulgular: En yüksek visfatin, TNF-α ve IL-1β seviyeleri (uDM+P+)grubunda tespit edildi (p>0.001). (uDM+P+) grubunda DOS visfatinseviyeleri ile DOS TNF-α ve DOS IL-1β seviyeleri arasında istatistikselolarak anlamlı pozitif korelasyonlar tespit edildi (p

Evaluation of Serum, Saliva and GCF Visfatin Levels in Chronic Periodontitis Patientswith Uncontrolled /Controlled Type2 Diabetes Mellitus

Background: The aim of this study is to investigate visfatinlevels in serum, saliva and GCF samples of non-diabetic CPpatients, CP patients with t2DM and ut2DM, and to evaluateof the relationship with clinical and biochemical parameters ofCP. Methods: Study protocol, 5 groups which each one wereconsisted of 15 subjects were planned: patients with bothperiodontal and systemic health (DM-P-); CP patients withsystemic health (DM-P+), periodontally healthy patients withdiabetes (DM+P-), patients with diabetes and CP (DM+P+),patients with uncontrolled diabetes and CP (uDM+P+).Serum, saliva and GCF samples were collected and levels ofvisfatin, TNF-α and IL-1β were determined by ELISA. Results: The highest levels of visfatin, TNF-α and IL-1β wereseen in (uDM+P+) group (p>0.001). Significant positivecorrelations between GCF visfatin levels and GCF TNF-α andIL-1β levels were detected in (uDM+P+) group (p

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