Bilal SARATAŞ, Mustafa TÜZ, Mehmet Emre SİVRİCE, Hasan YASAN, Kemal Kürşat BOZKURT

Plateletten Zengin Plazmanın Nazal Mukozada Yara İyileşmesine Etkisi

ÖzetAmaç: PRP nin nazal mukozada yara iyileşmesi üzerine olan etkilerini incelemekGereç ve yöntem: Çalışmamızda ağırlıkları 2.8-3.5 kg (ortalama 3.2 kg) ağırlığında 32 adet erkek Yeni Zelanda beyaz tavşanı kullanıldı. Sağ nazal kavitelerine girilerek interdental fırça yardımı ile (brushing technique) septum, konka ve lateral nazal duvarlarında mukozal hasar oluşturuldu. Hayvanlar birinci hafta ve üçüncü hafta olmak üzere iki gruba ve bu iki grup da kontrol ve PRP olmak üzere iki alt gruba ayrıldı.Bulgular: Histopatolojik skorlama sonuçlarına göre birinci hafta grubunda inflamasyonun şiddeti parametresi açısından istatistiksel olarak anlamlı fark saptandı (p=0,009).Diğer parametreler açısından birinci hafta ve üçüncü hafta gruplarında istatistiksel olarak anlamlı fark saptanmadı.Sonuçlar: Sonuçlarımız PRP nin yara iyileşmesinin erken aşamalarında inflamasyonu azalttığını göstermektedir. PRP nin nazal mukozal yara iyileşmesi üzerindeki etkilerinin anlaşılabilmesi için ileri çalışmalara ihtiyaç olduğu düşünülmektedir.

Anahtar Kelimeler:

plateletten zengin plazma, nazal mukoza, inflamasyon

Effects of Platelet-Rich Plasma (PRP) on Wound Healing in Nasal Mucosa

AbstractObjective: Study the effects of platelet-rich plasma (PRP) on wound healing in nasal mucosa.Materials and Methods: Thirty two adult New Zealand white rabbit of male sex were used for this study each weighing between 2800 and 3500 grams.Mucosal damage was created by interdental brush (brushing technique). The animals were randomly distributed into two groups as first week group and third week group. This two groups were subdivided into two subgroups as control and PRP.Results: According to the histopathologic scoring results, in first week group statistically significant difference was observed in term of inflammation severity between PRP and control subgroups (p =0.009). No statistically significant difference was observed between the other groups in terms of mucosal edema severity, loss of cilia degree between ciliary cells,fibrosis severity, goblet cell hyperplasia, inflammation severity, congestion and squamous metaplasia. Conclusion: Our results show that PRP reduces inflammation in early stages of wound healing. We believe further more studies are needed to understand the effects of PRP on nasal mucosal wound healing.

Keywords:

platelet-rich plasma, nasal mucosa, inflamation,

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