Kemal Kürşat BOZKURT, Özlem DURAK, İbrahim Metin ÇİRİŞ, Nilgün KAPUCUOĞLU, Tuba DEVRİM

Meme Kanserinde Moleküler Alt Tiplerin Klinikopatolojik Özelliklerle İlişkisi

Amaç: Meme kanserinde, moleküler alt tiplerin, klinikopatolojik özellikler (tanı yaşı, histolojik tip, histolojik derece, pT ve pN evreleri) ile ilişkilerinin tespit edilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışma grubu 194 kadın meme kanseri içermekteydi. Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi Patoloji Anabilim Dalı arşivi taranarak 2010-2015 yılları arasında meme kanseri tanısı verilmiş olgulara ait biyopsi ve radikal meme rezeksiyonu materyallerinin preparatları tekrar incelendi. Olguların immünhistokimyasal ER, PgR, HER2 ve Ki67 boyalı preparatları tekrar değerlendirilerek moleküler alt tiplendirme yapıldı. Bulgular: Tümör moleküler alt tipleri; %47,4 olguda Luminal A [ER ve/veya PgR(+)/HER2(-)/Ki67 ≤ %14], %25,8 olguda Luminal B [ER ve/veya PgR(+)/HER2(+) veya (-) /Ki67 > %14], %13,4 olguda HER2 overeksprese [ER(-)/PgR(-)/HER2(+)] ve %13,4 olguda ise üçlü negatif [ER(-)/PgR(-)/HER2(-)] idi. Tümör derecesi ve aksiller lenf nodu metastazı; Luminal B, HER2 overeksprese ve üçlü negatif tümörlerde Luminal A tümörlere göre daha yüksek izlendi. Luminal tip tümörlerle karşılaştırıldığında, HER2 overeksprese ve üçlü negatif tümörlerde lenfovasküler invazyon oranı anlamlı olarak daha fazla idi. Sonuç: Heterojen bir tümör grubu olan meme kanserlerinde evre ve diğer iyi bilinen klinikopatolojik özelliklerin yanında moleküler alt tiplendirmenin de hasta yönetimi için faydalı bilgiler verebileceği sonucuna varılmıştır.

Anahtar Kelimeler:

Meme, kanser, moleküler alt tip, immünhistokimya

The relationship of the molecular subtypes with the clinicopathological features in breast cancer

Objective: To determine the relationship between the molecular subtypes and the clinicalopathological features (age at the diagnosis, histological type, histological grade, pT and pN stages) in breast cancer.Materials and Methods: The study population included 194 women with breast carcinoma, who were diagnosed between 2010 and 2015. The slides of the cases in the archive of the Süleyman Demirel University Faculty of Medicine Department of Pathology were reevaluated. Immunohistochemical ER, PgR, HER2 and Ki67 stained slides were used to perform the molecular subtyping.Results: Among the cases molecular subtypes were; Luminal A [ER and/or PgR(+)/HER2(-)/Ki67 ≤ 14%] in 47.4% of cases, Luminal B [ER and/or PgR(+)/HER2(+) or (-) /Ki67 > 14%] in 25.8% of cases, HER2 overexpressing [ER(-)/PgR(-)/HER2(+)] in 13.4% of cases, and triple negative [ER(-)/PgR(-)/HER2(-)] in 13.4% of the cases, respectively. Tumor grade and axillary lymph node metastasis in Luminal B, HER2 overexpressing and triple negative tumors were significantly higher than they were in Luminal A tumors. Lymphovascular invasion rate was significantly higher in HER2 overexpressing and triple negative tumors compared to Luminal type tumors. Conclusions: It was concluded that the molecular subtyping of the breast carcinoma, which is a heterogeneous tumor group, can give important information for the management of the cases along with the stage and other well-known clinicopathological features.

Keywords:

Breast, cancer, molecular subtype, immunohistochemistry,

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