Fatih BAYGUTALP, Duygu ALTINTAŞ, Ayhan KUL

Fibromiyalji Sendromunda Demir Eksikliği ve Demir Eksikliği Anemisi Görülme Sıklığı

Amaç Etiyolojisi tam olarak bilinmeyen kronik bir ağrı durumu olan fibromiyalji sendromu (FMS) temel olarak yaygın ağrı, uyku bozuklukları, hafıza sorunları ve yaşam kalitesini ciddi şekilde bozan yorgunluk ile karakterizedir. Kandaki azalmış demir seviyelerinin bir sonucu olarak biyojenik amin nörotransmiterlerinin üretimindeki azalma FMS'nin patofizyolojisinde rol oynayabilir. Bu çalışmada FMS'li hastalarda demir eksikliği ve demir eksikliği anemisinin prevalansının araştırılması ve FMS'li hastalarda demir eksikliği prevalansına dikkat çekilmesi amaçlanmıştır. Gereç ve yöntem Hastanemiz fiziksel tip ve rehabilitasyon polikliniği’ne son beş yıl içinde müracaat eden hastalardan FMS tanısı alan ve serum ferritin, total demir bağlama kapasitesi (TDBK),vitamin B12 konstantrasyonları ile plazma hemoglobin konstantrasyonları belirlenmiş olan hastalar retrospektif olarak analiz edilmiştir. Veriler SPSS 23 paket programı kullanılarak analiz edilmiştir. Bulgular FMS'li kadın ve erkek hastalar arasındaki bağımsız grup karşılaştırmalarında, plazma hemoglobin ve serum demir düzeylerinin kadın hastalarda erkek hastalara göre anlamlı derecede düşük olduğu görülmüştür (sırasıyla, p = 0.009 ve p = 0.002). FMS'li erkek ve kadın hastalar arasında serum B12 düzeyleri ile serum ferritin düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu (sırasıyla p = 0.344, p = 0,093). Ayrıca, tüm FMS hastalarının % 28’inde demir eksikliği ve% 12'sinde demir eksikliği anemisi olduğu belirlenmiştir. Sonuç FMS tedavisinde başarının artırılması için FMS hastalarında serum ferritin seviyelerinin ölçülmesi ve gerektiğinde demir eksikliğinin tedavi edilmesi önerilmektedir.

Anahtar Kelimeler:

demir eksikliği, ferritin, fibromiyalji sendromu, sıklık

Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome

ObjectiveFibromyalgia syndrome (FMS), which is a chronic pain condition of unknown etiology, is mainly characterized by widespread pain, sleep disturbances, memory problems, and fatigue, which seriously impair quality of life. Decreased production of biogenic amine neurotransmitters as a result of decreased iron levels in the blood may play a role in the pathophysiology of FMS. This study aimed to investigate the prevalence of iron-deficiency and iron-deficiency anemia in patients with FMS and to draw attention to the prevalence of iron deficiency in patients with FMS. Material and MethodsThe patients who applied to the physical medicine and rehabilitation outpatient clinic of our hospital in the last five years, who were diagnosed as FMS and whose serum ferritin, total iron-binding capacity (TDBK), vitamin B12 concentrations and plasma hemoglobin concentrations were determined were analyzed retrospectively. Data were analyzed by using SPSS 23 package program. ResultsIn the independent group comparisons between female and male patients with FMS, both plasma hemoglobin and serum iron levels were significantly lower in female patients than in male patients (p =0.009 and p = 0.002, respectively). There were no statistically significant differences between serum vitamin B12 levels and serum ferritin levels between male and female patients with FMS (p= 0.344, p=0,093 respectively). Besides, iron deficiency and iron deficiency anemia were observed in 28% and 12% of all FMS patients, respectively. Conclusion Measuring serum ferritin levels in FMS patients and treating iron deficiency when necessary is recommended to increase the success of FMS treatment.

Keywords:

ferritin, fibromyalgia syndrome, frequency, iron-deficieny,

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