Sinnamaldehitin yeni schiff bazlarının sentezi ve antioksidan özelliklerinin incelenmesi

Bu çalışmada, sinnamaldehitin 9 yeni schiff bazı sentezlenmiş ve bu bileşiklerin 2,2-difenil-1-pikrilhidrazil radikal söndürücü kapasitesi (DPPH), Troloks eşdeğeri antioksidan kapasitesi (ABTS) ve bakır (II) iyonu indirgeyici antioksidan kapasitesi (CUPRAC) olmak üzere üç farklı yöntemle antioksidan aktivite özellikleri incelenmiştir. Bu bileşiklerin içinde (2,3-dihidroksibenziliden)amino)fenil)-5-fenilpenta-2,4-dien-1-on (4c) bileşiği her üç yönteme göre oldukça etkin bir şekilde antioksidan özellik göstermiştir. Ayrıca sentezlenen bileşiklerin yapı aktivite ilişkisi incelenerek bileşiklerin sahip oldukları grupların antioksidan aktiviteyi hangi yönde etkilediği ortaya konulmuştur.

Anahtar Kelimeler:

Sinnamaldehit, Schiff bazı, Antioksidan aktivite

Synthesis and antioxidant activities of new schiff bases of Cinnamaldehyde

In this study, 9 new schiff bases of cinnamaldehyde were synthesized and their antioxidant activities were examined by DPPH, ABTS and CUPRAC. Among the synthesized compounds, (2,3-dihydroxybenzylidene)amino)phenyl)-5-phenylpenta-2,4-dien-1-one (4c) showed high effective antioxidant activity for all three methods. In addition, the structure activity relationship of the synthesized compounds was examined, and it was revealed how the groups possessed by the compounds had an effect on antioxidant activity.

Keywords:

Cinnamaldehyde, Schiff base, Antioxidant activity,

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