Spinal Herniasyon Hastalarının Toplam Antioksidan Seviyeleri

Amaç: İnflamatuar yanıt disk bozulmalarında görülen önemli bir faktör olarak kabul görmüştür ve spinal herniasyon hastalarında acı hissinin ortaya çıkmasında önemli bir rolü olabilir. Bu çalışmanın amacı, cerrahi tedavi görmüş spinal herniasyon hastalarındaki toplam antioksidan statüsü (TAS), toplam oksidan statüsü (TOS) ve oranlanmalarından ortaya çıkan oksidatif stress endeksinin (OSE) ölçülmesi ve bu değerlerin toplanan yaş, cinsiyet ve herniasyon bölgesi arasında ilişki olup olmadığının araştırılmasıdır. Gereç ve Yöntemler: 19 kadın (48,72%) ve 20 erkek (51,28%) hasta çalışmaya dahil edilmiştir. TAS ve TOS seviyeleri laboratuvarda bulunan kitlerle ölçülmüş ve OSE bu değerlerin oranlanmasıyla elde edilmiştir (Rel Assay Diagnostics, Türkiye). Bulgular: Sonuçlar spinal herniasyonlu hastalarda ortalama TAS seviyesinin,1.518 ± 0.176, ortalama TOS seviyesinin 3.168 ± 0.956, ve ortalama OSE değerinin 0.222 ± 0.078 olduğunu %95 güven aralığıyla göstermektedir. Demografik ve herniasyon bölgesi değişkenlerinin TAS, TOS ve OSE değerleri üzerinde bir etkisi bulunamamıştır. Sonuç: Cerrahi tedavi görmüş spinal herniasyon hastalarının normal oksidatif durumda oldukları ve diğer değişkenlerin bu bulgu üstünde etkisi yoktur.

Anahtar Kelimeler:

Spinal herniasyon, antioksidan, serbest radikal, oksidatif stres

Total Antioxidant Levels in Patients with Spinal Herniation

Objective: Inflammatory response has been acknowledged to be an important factor in the process of disc degeneration and may play an important role in generation of pain, among patients with spinal herniation. The aim of this study is to investigate the total antioxidant status (TAS), total oxidant status (TOS), and their ratio, oxidative stress index (OSI) in patients with spinal herniations, and the relationship between these dependent variables and location of herniation, gender and age. Materials and Methods: 19 female (48,72%) and 20 male (51,28%) patients are included in the study. TAS and TOS levels are measured by commercially available kits in laboratory (Rel Assay Diagnostics, Turkey). OSI levels are calculated by their ratio. Results: Results show that mean TAS level is 1.518 ± 0.176, mean TOS level is 3.168 ± 0.956, and mean OSI level is 0.222 ± 0.078 with 95 % confidence interval. No correlations are found between age with the TAS, TOS and OSI levels. Conclusion: Post-operative patients with spinal herniation have normal oxidative statuses and the location of herniation and gender seems to have no effect on the TAS, TOS and OSI levels.

Keywords:

spinal herniation, antioxidant, free radical, oxidative stress,

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