Mahizar Yaldız, Nur Cihan Cosansu, Bahar Sevimli Dikicier, Berna Solak

Psöriyazis Hastalarında Monosit / Lenfosit Oranı ile Hastalığın Varlığı ve Şiddeti Arasında Bir İlişki Var Mıdır?

Amaç Psöriyazis’li hastalar, genel popülasyona kıyasla artmış sistemik inflamasyon ve monosit seviyelerine sahiptir. Bununla birlikte, bu hastalarda monositlerin enflamasyonu modüle etmedeki rolü açıkça bilinmemektedir. Enflamasyonun rol oynadığı psöriyazis hastaları kardiyovasküler hastalıklar içinde risk altındadır. Monosit-lenfosit oranı (MLO) sistemik bir enflamatuar durumu yansıtabilir. Bu çalışmanın amacı psöriyazis hastalarında MLO’nın yararlılığını araştırmaktır. Gereç ve Yöntemler Vaka-kontrol çalışmamıza Ocak 2015 ile Ocak 2017 arasında psöriyazis polikliniğine rutin olarak yönlendirilen toplam 180 ardışık hasta ve 40 sağlıklı birey dahil edildi. Demografik özellikler, Psöriyazis Alan ve Şiddet İndeksi (PASI) skorları ve laboratuvar verileri elektronik veri tabanı sisteminden toplandı. Bulgular Psöriyazis hastalarında kontrol grubuna kıyasla daha yüksek lökosit, nötrofil, monosit sayısı ve MLO vardı (sırasıyla p = 0.003, p

Is There Any Association Between the Monocyte / Lymphocyte Ratio and the Presence and Severity of the Disease in Patients with Psoriasis?

Objective Patients with psoriasis have increased systemic inflammation and monocytes levels compared with the general population. However, the role of monocytes in modulatinginflammation in these patients is not clearly known. Psoriasis patients, where inflammation plays a role, are also at risk for cardiovascular diseases. The monocyte-tolymphocyte ratio (MLR) may reflect a systemic inflammatory status. The aim of this study was to investigate the usefulness of MLR in patients with psoriasis.Materialsand MethodsA total of 180 consecutive patients who had been routinely referred to psoriasis outpatient clinic,and 40 healthy individuals were included in our case-control study betweenJanuary 2015, and January 2017. Demographic features, Psoriasis Area and Severity Index (PASI) scores,and laboratory data were collected from electronic database system.Results Patients with psoriasis had higher leukocyte, neutrophil, monocyte counts and MLR compared with control group (p=0.003, p

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