İskemik ve Hemorajik İnme Hastalarında Kan Lipid Parametrelerinin Karşılaştırılması ve Mortalite ile İlişkisi

Amaç: Çalışmada iskemik ve hemorajik inme hastalarında kan lipid parametrelerinin değerlendirilmesi ve mortalite ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Retrospektif özellikte, kesitsel ve hastane temelli klinik bir çalışma olarak planlandı. İskemik ve hemorajik inme tanısı klinik bulgular, beyin difüzyon ağırlıklı manyetik rezonans görüntüleme (MRG) ve bilgisayarlı tomografi (BT) ile konfirme edildi. Hastane içi inme mortalite oranları hesaplandı. Hastaların serum lipid profili (trigliserid, total kolesterol, yüksek dansiteli lipoprotein (HDL) kolesterol ve düşük dansiteli lipoprotein (LDL) kolesterol) incelendi. Bulgular: Çalışmada 60 iskemik ve 50 hemorajik inme hastası dahil edildi. İskemik ve hemorajik inme guruplarında diyabetes mellitüs (DM) ve koroner arter hastalığı (KAH) sıklığı benzerdi (sırasıyla p: 0,649, p: 0,919). Hipertansiyon hemorajik inme gurubunda daha sıktı (p: 0,006). Mortalite oranları iskemik inmede %10 (n: 6), hemorajik inmede %36 (n: 18) idi. İskemik inme ve hemorajik inmede serum lipid seviyeleri karşılaştırıldığında, total kolesterol iskemik inme gurubunda yüksekti (p: 0,003). Trigliserit, HDL ve LDL kolesterol seviyesi benzerdi (sırasıyla, p: 0,929, p: 0,443, p: 0,133). Mortalite ile seyreden tüm inme hastalarında serum trigliserid ve total kolesterol seviyesi daha düşüktü (p=0,047, p=0,002). Diğer parametreler benzerdi. Sonuç: Çalışmamızda serum total kolesterol seviyesi iskemik inme hastalarında daha yüksektir. Hipertansiyon hemorajik inmede daha sıktır. Trigliserit ve total kolesterol düşüklüğü inme hastalarında kısa dönem mortalite ile ilişkilidir.

Anahtar Kelimeler:

Hemorajik inme, iskemik inme, lipidler, prognoz, risk faktörleri

Comparison of Blood Lipid Parameters in Patients with Ischemic and Hemorrhagic Stroke and Its Relationship with Mortality

Objective: The aim of this study is to evaluate blood lipid parameters in patients with ischemic and hemorrhagic stroke and its relationship with mortality. Materials and Methods: For the study, patients with acute ischemic stroke and hemorrhagic stroke who received inpatient treatment in the neurology clinic between January 2017 and October 2020 were retrospectively analyzed. In-hospital ischemic and hemorrhagic stroke mortality rates were calculated. The lipid profile of the patients (triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol) was evaluated with blood samples taken after 12 hours of fasting. Results: There were 60 ischemic and 50 hemorrhagic stroke patients in the study. The frequency of diabetes mellitus (DM) and coronary artery disease (CAD) were similar in groups with ischemic and hemorrhagic stroke (p: 0,649, p: 0,919, respectively). Hypertension was higher in the hemorrhagic stroke group (p: 0,006). Mortality rates were 10% (n: 6) in ischemic stroke and 36% (n: 18) in hemorrhagic stroke. Comparison of serum lipid levels in ischemic stroke and hemorrhagic stroke; Total cholesterol was higher in ischemic stroke group (p: 0,003). Triglyceride, HDL, and LDL cholesterol levels were similar in groups (p: 0,929, p: 0,443, p: 0,133, respectively). Serum triglyceride and total cholesterol levels were lower in all stroke patients with mortality (p: 0,047, p: 0,002). Other parameters were similar. Conclusion Serum total cholesterol level is higher in patients with ischemic stroke. Hypertension is more common in hemorrhagic stroke. Low triglycerides and low total cholesterol are associated with short-term mortality in patients with stroke.

Keywords:

Hemorrhagic stroke, ischemic stroke, lipids, prognosis, risk factors,

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