Muzaffer KATAR, Murat BEYHAN, Osman DEMİR

Eozinofil Katyonik Protein, Covid-19 Tanısında Kullanışlı Bir Biyobelirteç Olabilir Mi?

Amaç Covid-19 hastalığı, moleküler, serolojik veya radyolojik yöntemlerle teşhis edilir. Bununla birlikte, bu teşhis yöntemlerine her yerde ulaşılamaz veya sonuçlanması çok fazla zaman alabilir. Bu nedenle, Covid-19 hastalarının basit ve kolay erişilebilir laboratuvar biyobelirteçleri ile etkili teşhisine ihtiyacımız var. Bu nedenle Covid-19'da Eozinofilik Katyonik Proteinin (ECP) tanısal performansını araştırdık. Gereç ve yöntemler Çalışmamız geriye dönük bir vaka-kontrol çalışmasıdır. 15 Mart - 15 Haziran 2020 tarihleri arasında Covid-19 teşhisi konulan 30 hastanın kaydedilen klinik, laboratuvar ve radyolojik verileri uygun istatistiksel yöntemler kullanılarak 30 sağlıklı kişi ile karşılaştırıldı. Sonuçlar Hastalar ve kontroller sırasıyla ortalama yaşları 57,2 ± 15,46 ve 60,07 ± 20,59 olan 10 (% 33,3) kadın ve 20 (% 66,6) erkeklerdi. Hastaların başvuru sırasındaki eozinofil sayıları kontrollere göre anlamlı olarak düşüktü (p

Anahtar Kelimeler:

Covid-19, Tanı, ECP, Eozinopeni, Lenfopeni, Nötropeni

Could Eosinophil Cationic Protein Be A Useful Biomarker In The Diagnosis Of Covid-19?

Objective Covid-19 disease is diagnosed by moleculer, serologic or radiological methods. However, these diagnostic methods cannot be reached everywhere or take too much time to result. So, we need for effective diagnosis of Covid-19 patients with simple and easy accessible laboratory biomarkers. Therefore, we investigated the diagnostic performance of Eosinophilic Cationic Protein (ECP) in Covid-19. Material and Methods Our study is a retrospective case-control study. The recorded clinical, laboratory and radiological data of 30 patients who were diagnosed with Covid-19, between 15 March and 15 June 2020, were compared with 30 healthy person by using appropriate statistical methods. Results Both patients and conrols included 10 (33.3%) females and 20 (66.6%) males with a mean age of 57.2 ± 15.46 and 60.07 ± 20.59 respectively. Eosinophil counts of the patients at admission were significantly lower than the controls (p

Keywords:

Covid-19, Diagnosis, ECP, Eosinopenia, Lymphopenia, Neutropenia,

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