Yusuf CAN, Salih ŞAHİNKUŞ, İbrahim KOCAYİĞİT, Muhammed N Murat AKSOY, Selcuk YAYLACI, Altuğ ÖSKEN, Huseyin GÜNDÜZ, Ercan AYDIN, Harun KILIÇ, Ramazan AKDEMİR

Subklavyen Arter Darlığı olan Hastalarda Ortalama Trombosit Hacmi

Amaç: Trombositler ve ortalama trombosit hacmi ateroskleroz ile ilişkilidir. Bu çalışmanın amacı, ortalama trombosit hacmi ile subklavyen arter darlığı arasındaki ilişkiyi araştırmaktı. Materyal ve Metod: Sakarya Üniversitesi Eğitim ve Araştırma Hastanesi kateter laboratuvarında Eylül 2010 - Eylül 2015 tarihleri arasında yapılan anjiyografi ile subklavyen arteriyel darlık tanısı alan hastalar retroolarak çalışmaya dahil edildi. Subklavyen arteriyel darlık hastaları ile anjiyografik açıdan benzer klinik ve demografik özelliklere sahip bir kontrol grubu oluşturuldu. Subklavyen arteriyel darlık hastaları (35 hasta) ve kontrol grubundaki hastalar (38 hasta) için ortalama trombosit hacmi ve diğer hemogram değerleri kayıt sisteminden geriye dönük olarak belirlenmiş ve karşılaştırılmıştır. Bulgular: İki grup yaş, cinsiyet, ateroskleroz risk faktörleri, koroner arter hastalığı öyküsü ve ilaç kullanımı açısından birbirine benzerdi. Gruplar arasında hemogram parametreleri karşılaştırıldığında, ortalama trombosit hacmi subklavyen arteriyel darlığı olan hastalarda control grubuna göre anlamlı olarak yüksek saptandı (8.07 ± 1.41 vs 7.19 ± 0.52; p = 0.001). Sonuç: Sonuç olarak, bu çalışma subklavyen arter darlığı olan hastalarda daha yüksek ortalama trombosit hacmi bulan ilk çalışma olmuştur. Hem trombositlerin ateroskleroz üzerindeki etkisi hem de diğer risk faktörleri ile yakın ilişkisi düşünüldüğünde MPV düzeyi subklavyen arter darlığının patogenezinde önemli bir faktör olabilir.

Anahtar Kelimeler:

Ateroskleroz, subklavyen arter darlığı, ortalama trombosit hacmi

Mean Platelet Volume in Patients with Subclavian Arterial Stenosis

Objective: Thrombocytes and mean platelet volume (MPV) are related to atherosclerosis. The purpose of the present study was to investigate the relationship between MPV and subclavian arterial stenosis (SAS). Materials and Methods: Patients who were diagnosed with SAS by an angiography performed in the catheter laboratory between September 2010 and September 2015 were included in this study. A control group with similar clinical and demographic characteristics as the patients with SAS in angiographic terms was formed. The MPV and other hemogram values for SAS patients (35 patients) and the patients in the control group (38 patients) were determined retrospectively from the registry system and then compared. Results: The two groups were similar to each other in terms of demographic and clinical characteristics. When the hemogram parameters were compared between the groups, the MPV was detected as being significantly higher in patients with SAS (8.07 ± 1.41 vs 7.19 ± 0.52; p = 0.001). Conclusion: In conclusion, this study was the first to find a higher MPV in patients with SAS. Considering both the effect of platelets on atherosclerosis and their close association with other risk factors, MPV level may be an important factor in pathogenesis of SAS.

Keywords:

Atherosclerosis, subclavian arterial stenosis, mean platelet volume,

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