Ali Rıza AKYÜZ, Ahmet ÖZDERYA, Ali Hakan KONUŞ

Asemptomatik Hastalarda Aort Kapak Sklerozu ile Kalp-Ayak Bileği Damar İndeksi ve Klinik Faktörler Arasındaki İlişki

Amaç: Bu çalışma, bilinen kardiyovasküler (KV) hastalığı olmayan asemptomatik bireylerde aort kapak sklerozu (AVS) ile arteriyel sertlik arasındaki ilişkiyi incelemeyi amaçlamıştır. Hem AVS hem de arteriyel sertlik ateroskleroz ile ilişkilidir ve daha önceki çalışmalarda KV hastalıklarla yakından ilişkili bulunmuştur. . Bu çalışmada, CAVI ile değerlendirilen arteriyel sertlik ile AVS arasındaki ilişkiyi incelemeyi amaçladık. Yöntemler: Kardiyoloji polikliniğine başvuran hastalar sırayla çalışmaya dahil edildi. Olgular dışlama kriterlerine göre analiz edildi. Çalışmaya yüz altmış beş hasta dahil edildi ve bunların 35'inde (%21) AVS tespit edildi. Geriye kalan 130 (%79) hasta kontrol grubuna alındı. Ekokardiyografi ile AVS, VaSera VS-1000 CAVI cihazı ile arter sertliği ölçüldü. 9 ve üzeri CAVI değeri anormal olarak kabul edildi. İstatistikler AVS olan ve olmayan gruba göre yapılmıştır. Bulgular: CAVI, AVS ve kontrol grupları arasında istatistiksel olarak farklıydı (9,47±1,64 vs. 7,60±1,27 p< 0,001). Pearson korelasyon testi, AVS ile artan CAVI değerleri arasındaki korelasyonu belirledi (p< 0,001). Çok değişkenli lojistik regresyon analizi modelinde, artan CAVI (OR: 2.048, %95 CI 1.183-3.547, p: 0.010) için bağımsız bir öngörücüydü. AVS.Diğerleri yaş (p:0.026) ve diabetes mellitus (p:0.037) olarak bulundu. Sonuç: AVS ile arteriyel sertlik arasındaki ilişki aterosklerotik süreç ile ilişkilidir. Ekokardiyografi sırasında AVS saptanan veya CAVI değerleri yüksek olan asemptomatik bireylerin diğer KV hastalıklarda dikkatli araştırılması ve düzenli takibi önemlidir.

Anahtar Kelimeler:

Aort kapak sklerozu, Arterial Sertlik, Asemptomatik hastalar, Kalp-ayak bileği damar indeksi

The Relationship Between Cardio-Ankle Vascular Index and Clinical Factors with Aortic Valve Sclerosis in Asymptomatic Patients

Objectives: This study aimed to examine the relationship between aortic valve sclerosis (AVS) and arterial stiffness in asymptomatic individuals without known cardiovascular (CV) disease.Both AVS and arterial stiffness are associated with atherosclerosis and have been closely related to CV diseases in previous studies. In this study, we aimed to examine the relationship between arterial stiffness assessed by CAVI and AVS. Methods: Patients who applied to the cardiology outpatient clinic were included in the study sequentially. Subjects were analyzed according to exclusion criteria.One hundred sixty-five patients were included in the study, and AVS was detected in 35 (21%) of them. The remaining 130 (79%) patients were included in the control group.AVS was measured with echocardiography, and arterial stiffness was measured with the VaSera VS-1000 CAVI device. A CAVI value of 9 and above was accepted as abnormal. Statistics were made according to the group with and without AVS. Results: CAVI was statistically different between the AVS and control groups(9.47±1.64 vs. 7.60±1.27 p< 0.001). The Pearson correlation test determined the correlation between AVS and increased CAVI values (p< 0.001).In the multivariable logistic regression analysis model, increased CAVI (OR: 2.048, 95%CI 1.183-3.547, p: 0.010) was an independent predictor for AVS.Others were found as age (p:0.026) and diabetes mellitus (p:0.037). Conclusions: The relationship between AVS and arterial stiffness is associated with the atherosclerotic process.Careful investigation and regular follow-up of asymptomatic individuals with AVS detected during echocardiography or increased CAVI values are important in other CV diseases.

Keywords:

Aortic valve sclerosis, Arterial stiffness, Asymptomatic patients, Cardio-Ankle Vascular Index (CAVI),

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