Alp Şener, Hatice Çiftçi Sivri, Serkan Sivri, Ahmet Ertem, Gülhan Kurtoğlu Çelik, Cemal Köseoğlu, Ferhat İçme, Şervan Gökhan, Engin Bozkurt

Akut Pulmoner Emboli Tanısı Almış Hastalarda Platelet/Lenfosit Oranının Kısa Dönem Mortaliteyi Ön Gördürmedeki Prognostik Değeri

Amaç Pulmoner emboli yüksek mortalite ve morbidite oranları ile inflamatuvar bileşeni iyi bilinen bir hastalıktır. Platelet / lenfosit oranı, kalpve çeşitli onkolojik hastalıklarda mortalitenin bağımsız belirleyicisi olan inflamasyonun yeni bir belirtecidir. Bu çalışmanın amacı, akutpulmoner emboli hastalarında kısa süreli mortalite için platelet / lenfosit oranının prognostik değerini belirlemektir.Materyal ve Metot: Acil servise başvuran ve akut PE tanısı toplam 290 hasta çalışmaya retrospektif olarak alındı . Akut pulmoner emboli çok kesitli bilgisayarlıtomografi ile teyit edildi.Bulgular: Pulmoner emboli tanısı alan 290 hastanın, tanı aldıktan sonra 53’ü (%18,2) 1 ay içinde öldü. Yaş, malignite, koroner arter hastalığı, sağventrikül dilatasyonu, hemoglobin beyaz kan hücresi nötrofil ve trombosit sayımları sistolik pulmoner arter basıncı nötrofil / lenfositoranı platelet / lenfosit oranı ve pulmoner emboli ciddiyet indeksi grup 1'de grup 2’ye göre anlamlı derecede yüksek bulundu. Platelet/ lenfosit oranının 176.31 ve üzerinde olması akut pulmoner emboli sonrası 30 günlük mortaliteyi predikte ettirmedeki duyarlılığı %79ve özgüllüğü %70’ti. Platelet / lenfosit oranı, hemoglobin ve basitleştirilmiş pulmoner emboli ciddiyet indeksi, akut pulmoner embolitanısı almış hastalarda mortalitenin bağımsız bir belirleyicisiydi.Sonuç: Platelet / lenfosit oranı, pulmoner emboli sonrası erken dönemde mortalite gelişen hastalarda, mortalite gelişmeyenlere göre dahayüksekti. Bu sebeple, platelet / lenfosit oranı gibi ucuz ve pratik bir parametre akut pulmoner embolide mortalite risk tahminindekullanılabilir

Anahtar Kelimeler:

Platelet / lenfosit oranı, pulmoner emboli, mortalite

The Prognostic Value of The Platelet/Lymphocyte Ratio in Predicting Short-Term Mortality in Patients with Acute Pulmonary Embolism

Objectıves: Pulmonary embolism (PE), which has an inflammatory component, has high mortality and morbidity rates. The platelet/lymphocyteratio is a novel marker of inflammation that is an independent predictor of mortality in cardiac and various oncological diseases. Theaim of the present study was to determine the prognostic value of the platelet/lymphocyte ratio for short-term mortality for patientswith acute pulmonary embolism.Materialsand Methods:A total of 290 patients who were admitted to the emergency department and diagnosed with acute PE were enrolled retrospectively.Acute pulmonary embolism was confirmed via multislice computerized tomography.Results: Of the 290 patients, 53 (18.2%) died within 1 month after the diagnosis was made. Age, malignancy, coronary artery disease, rightventricular dilatation, hemoglobin, white blood cell, neutrophil, and platelet counts, systolic pulmonary artery pressure, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and pulmonary embolism severity index were significantly higher in group 1 than in group2. The platelet/lymphocyte ratio, hemoglobin, and simplified pulmonary embolism severity index were independent predictors of mortality in patients with acute pulmonary embolism. A platelet/lymphocyte ratio of more than 176.31 predicted the presence of mortalitywithin 30 days after acute pulmonary embolism with a sensitivity of 79% and a specificity of 70%.Conclusion: Platelet/lymphocyte ratios were higher in patients who died within 30 days of PE than those who did not. An inexpensive and practicalparameter such as the platelet/lymphocyte ratio might be useful in mortality risk prediction in acute pulmonary embolism.

Keywords:

Platelet/lymphocyte ratio, pulmonary embolism, mortality,

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