Erdem ÇOKLUK, Ramazan ŞEKEROĞLU, Emine YILMAZ

Agmatin Biyokimyası: Şizofreni ve Depresyondaki Rolüne Bakış

Agmatin imidazolin reseptör agonisti olup çok sayıda reseptörle etkileşebilen nöroprotektif, anti-enflamatuvar, anti-stres, anti-depresan özellikte, kognitif fonksiyonların düzenlenmesinde rol alan bir moleküldür. Agmatinin beyindeki inaktivasyonu, reuptake mekanizmaları ve enzimatik parçalanmayla gerçekleşmektedir. Gerialımı diğer nörotransmitterlerden farklı olarak sıcaklığa bağlı gerçekleşmekte ve sadece yüksek konsantrasyonlarda doygunluğa ulaşabilmektedir. Ayrıca, agmatinin streste arttığı, dolayısıyla majör depresyon hastalarında akut dönemde tedavi sonrası döneme göre plazma agmatin düzeylerinin daha yüksek olduğu da bildirilmiştir. Bununla birlikte şizofreni gelişmeden önceki süreçte agmatin eksikliğinden, şizofreni geliştikten sonraki dönemde ise agmatin artışından bahseden çalışmalar da literatürde mevcuttur. Bu derlemede agmatinin biyokimyası, şizofreni ve depresyondaki rolü ve nöroprotektif etkisi irdelenmiştir.

Anahtar Kelimeler:

Agmatin, şizofreni, depresyon, nöroprotektif etki

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