ÇİNKO, FONKSİYONLARI VE İMMÜN SİSTEMDEKİ ROLÜ

Çinko (Zn), organizma için temel minerallerden biridir. Optimal sağlık için her gün belirli bir miktarda alınması gereken bir eser elementtir. Hayati öneme sahip olan çinkonun vücuttaki düzeyini korumak için kullanılabilecek bir çinko depose yoktur. Çinko, spesifik çinko taşıyan proteinler tarafından bağırsakta emilir ve insane vücudunda dağıtılır. Serumda serbest çinko nadirdir; çünkü albümin, α2-makroglobulin ve transferrin gibi proteinlere büyük oranda bağlıdır. Çinko eksikliğinde polimorfo nükleer hücreler kemotaksisi ve fagositoz azalırken, çinko takviyesi tam tersi bir etkiye sahiptir. Patojenler, fagositoz sonrasında çinko yetersizliği veya fazlalığı sonucu inhibe edildiği gösterilen nikotin amidadenin dinükleotid fosfatoksidazlarının aktivitesi ile yok edilir.

Anahtar Kelimeler:

çinko, çinko bağlayıcı protein, immun sistem

ZINC, ITS FUNCTIONS AND ROLE IN THE IMMUNE SYSTEM

Zinc (Zn) is the essential mineral for the organism. It is a biological trace element that needs to be taken every day for optimal health. Despite the vital necessity of Zn, the body has no warehouse that can be used to maintain metal levels for a long time. Zinc is absorbed in the intestine by specific zinc-bearing proteins and distributed in the human body. Free zinc is rare in serum because albumin is highly attached on proteins such as α2-macroglobulin and transferrin. During zinc deficiency, while polymorphonuclear cells chemotaxis and phagocytosis decreased, zinc supplementation had the opposite effect. Pathogens are destroyed by the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases which have been shown to be inhibited by both zinc deficiency and excess after phagocytosis.

Keywords:

immune system, zinc, zinc-binding protein,

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