BAZI YENİ [1,2,4]TRIAZOLO[3,4-b][1,3,4]TİYADİAZOL TÜREVLERİNİN SENTEZİ VE DENEYSEL KARAKTERİZASYONU
Bu çalışmada, salisilik ve izonikotinik asit hidrazit bileşikleri dönüştürüldü. [1,2,4] triazolo[3,4-b] [1,3,4]tiyadiazol-6(5H)-tiyon 2a,b bileşik serisi aminomerkaptotriazollerden 1a,b sentezlendi. Aminomerkaptotriazol bileşikleri 2a,b ile aromatic karboksilik asit ve fosfor oksiklorürün reaksiyonundan iyi verimle yeni 3-substitüe[1,2,4]triazolo[3,4-b] [1,3,4]tiyadiazol türevleri 3a-h sentezlendi. Sentezlenen bileşiklerin yapıları IR, 1H-NMR and 13C-NMR spektrofotometreleri kullanılarak aydınlatıldı
Anahtar Kelimeler:
1, 2, 4-triazol, Aminomerkaptotriazoller, Tiyadiazol, Hidrazit, Fosfor Oksiklorür
SYNTHESIS AND EXPERIMENTAL CHARACTERIZATION OF SOME NEW [1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZOLE DERIVATIVES
In this study, salicylic and izonicotinic acid hydrazide was converted into 4-amino 5-substituted-4H-1,2,4-triazole-3-thiol 1a,b. A series of [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole-6(5H)-thione 2a,b were prepared from aminomercaptotriazoles. The reaction of aminomercaptotriazole compounds 2a,b with aromatic carboxylic acid and phosphorus oxychloride afforded the newly synthesized 3-substituted-[1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole derivatives 3a-h in good yields. In addition, the structures of synthesized compounds were confirmed by IR, 1H-NMR and 13C-NMR spectra.
Keywords:
1, 2, 4-triazole, Aminomercaptotriazoles, Thiadiazole, Hydrazide, Phosphorus Oxychloride.,
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- Başlangıç: 2009
- Yayıncı: E-Journal of New World Sciences Academy