Akut miyokart enfarktüsü olan hastalarda sorumlu lezyonun bifurkasyon lezyon olma sıklığı: seçilen tedavi stratejisinin erken ve geç dönem sonuçlara etkisi

Amaç: Bifurkasyon lezyonu olan hastalarda provizyonel teknik ile çift stent tekniğini karşılaştıran çalışmalar mevcuttur. Ancak, miyokart enfarktüsü (ME) tanısı alan ve bifurkasyon lezyonu saptanan hastalarda revaskülarizasyon tekniği ile ilgili çalışmalar yeterli değildir. Çalışmamızda ME tanısı alan ve bifurkasyon lezyonu saptanan hastalarda provizyonel yöntem ve çift stent tekniğinin erken ve geç dönem sonuçları üzerine olan etkisini araştırmayı amaçladık.Gereç ve yöntem: Miyokart enfarktüsü tanısı alan 2992 hastadan bifurkasyon lezyonu olan 385 hasta çalışmaya dahil edildi. Hastaların Synergy between PCI with TAXUS™ and Cardiac Surgery (SYNTAX) skoru, işlem öncesi Thrombolysis in Myocardial Infarction (TIMI) skoru, işlem süresi, anjiyografik özellikleri, işlem sonrası TIMI skoru, işlem sonrası yan dal kaybı, 30 günlük ve 1 yıllık mortalite bilgileri değerlendirildi. Bulgular: 169 (%43,9) hasta ST segment yükselmeli miyokart enfarktüsü (STYME), 216 (%56,1) hasta ST segment yükselmesi olmayan miyokart enfarktüsü (NSTYME) olarak değerlendirildi. 355 (%92,2) hastaya provizyonel teknik, 30 (%7,8) hastaya çift stent tekniği uygulandı. Provizyonel stentleme uygulanan hastaların 40’ında (%11,2) yan dal kaybı gelişti. Çift stent tekniği uygulanan hastaların 1’inde (%3,3) yan dal kaybı meydana geldi (p=0,2). Çift stent tekniği uygulanan hastalarda anjiyografi süresi ve işlem süresi anlamlı olarak daha uzundu (p

Incidence of bifurcation coronary lesion as a culprit lesion in patients with acute myocardial infarction: impact of treatment strategy on short and long term outcomes

Purpose: Although, there are several studies comparing single and two-stent techniques in patients with bifurcation lesions, evidence in patients presenting with myocardial infarction (MI) is still insufficient. We aimed to assess the short and long term outcomes of provisional and two-stent techniques of bifurcation lesions in patients with ACS. Materials and methods: 2992 patients with MI who underwent percutaneous coronary intervention (PCI) were enrolled in the present study. Of 2992 patients, 385 patients with MI had bifurcation lesions. The Synergy between PCI with TAXUS™ and Cardiac Surgery (SYNTAX) score, pre-PCI Thrombolysis in Myocardial Infarction (TIMI) flow, post-PCI TIMI flow, duration of procedure, angiographic features, post-PCI side branch loss, 1- and 12-month mortality rates were noted. Results: 169 (43.9%) patients had ST segment elevation MI, whereas 216 (56.1%) patients had non-ST segment elevation MI. 355 (92.2%) patients underwent provisional stenting and 30 (7.8%) patients underwent two-stent technique. Side branch loss was observed in 40 patients (11.2%) in the provisional group and 1 patient (3.3%) in the two-stent group (p=0.2). Compared to provisional group, durations of angiography and revascularization in two-stent group were significantly longer (p

___

  • Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation 1995;92:657-671. https://doi. org/10.1161/01.cir.92.3.657
  • Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999;340:115-126. https://doi.org/10.1056/ NEJM199901143400207
  • Fuster V, Badimon L, Badimon J, et al. The pathogenesis of coronary artery disease and acute coronary syndromes. N Engl J Med 1992;326:242- 250. https://doi.org/10.1056/NEJM199201233260406
  • Takebayashi H, Haruta S, Kohno H, et al. Immediate and 3-month follow-up outcome after cutting balloon angioplasty for bifurcation lesions. J Interv Cardiol 2004;17:1-7. https://doi.org/10.1111/j.1540- 8183.2004.00246.x
  • Yamashita T, Nishida T, Adamian MG, et al. Bifurcation lesions: two stents versus one stent--immediate and follow-up results. J Am Coll Cardiol 2000;35:1145- 1151. https://doi.org/10.1016/s0735-1097(00)00534-9
  • Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 2012;60:1581-1598. https://doi.org/10.1016/j. jacc.2012.08.001
  • Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention 2005;219- 227.
  • TIMI Study Group. The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med 1985;312:932-936. https://doi. org/10.1056/NEJM198504043121437
  • Thomas M, Hildick-Smith D, Louvard Y, et al. Percutaneous coronary intervention for bifurcation disease: a consensus view from the first meeting of the European Bifurcation Club. EuroIntervention 2006;2:149-153.
  • Sang Song P, Ryeol Ryu D, Choi SH, et al. Impact of acute coronary syndrome classification and procedural technique on clinical outcomes in patients with coronary bifurcation lesions treated with drug-eluting stents. Clin Cardiol 2012;35:610-618. https://doi.org/10.1002/ clc.22020
  • Kim MC, Ahn Y, Sun Sim D, et al. Comparison of the planned one- and elective two-stent techniques in patients with coronary bifurcation lesions with or without acute coronary syndrome from the COBIS II Registry. Catheter Cardiovasc Interv 2018;92:1050- 1060. https://doi.org/10.1002/ccd.27551
  • Hildick Smith D, de Belder AJ, Cooter N, et al. Randomized trial of simple versus complex drugeluting stenting for bifurcation lesions: the British Bifurcation Coronary Study: old, new, and evolving strategies. Circulation 2010;121:1235-1243. https:// doi.org/10.1161/CIRCULATIONAHA.109.888297
  • Chen SL, Santoso T, Zhang JJ, et al. A randomized clinical study comparing double kissing crush with provisional stenting for treatment of coronary bifurcation lesions: results from the DKCRUSH-II (Double Kissing Crush versus Provisional Stenting Technique for Treatment of Coronary Bifurcation Lesions) trial. J Am Coll Cardiol 2011;57:914-920. https://doi. org/10.1016/j.jacc.2010.10.023
  • Maeng M, Holm NR, Erglis A, et al. Long-term results after simple versus complex stenting of coronary artery bifurcation lesions: Nordic Bifurcation Study 5-year follow-up results. J Am Coll Cardiol 2013;62:30-34. https://doi.org/10.1016/j.jacc.2013.04.015
  • Colombo A, Bramucci E, Sacca S, et al. Randomized study of the crush technique versus provisional side-branch stenting in true coronary bifurcations: The CACTUS (Coronary bifurcations: Application of the Crushing Technique Using Sirolimus-eluting stents) study. Circulation 2009;119:71-78. https://doi. org/10.1161/CIRCULATIONAHA.108.808402
  • Lassen JF, Holm NR, Banning AP, et al. Percutaneous coronary intervention for coronary bifurcation disease: consensus from thefirst 10 years of the European Bifurcation Club meetings. Euro Interventiol 2014;10:545-560. https://doi.org/10.4244/EIJV10I5A97
  • Chen SL, Zhang JJ, Han Y, et al. Double kissing crush versus provisional stenting for left main distal bifurcation lesions: DKCRUSH-V randomized trial. J Am Coll Cardiol 2017;70:2605-2617. https://doi. org/10.1016/j.jacc.2017.09.1066
  • Neumann FJ, Sousa Uva M, Ahisson A, et al. 2018 ESC/ EACTS Guidelines on myocardial revascularization. Eur Heart J 2019;40:87-165. https://doi.org/10.1093/ eurheartj/ehy394
  • Cervinka P, Foley DP, Sabate M, et al. Coronary bifurcation stenting using dedicated bifurcation stents. Catheter Cardiovasc Interv 2000;49:105-111. https://doi. org/10.1002/(sici)1522-726x(200001)49:1<105::aidccd25>3.0.co;2-2
  • Timurkaynak T, Ciftci H, Ozdemir M, et al. Side branch occlusion after coronary stenting with or without balloon predilation: direct versus conventional stenting. J Invasive Cardiol 2002;14:497-501.
Pamukkale Tıp Dergisi-Cover
  • ISSN: 1309-9833
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2008
  • Yayıncı: Prof.Dr.Eylem Değirmenci
Sayıdaki Diğer Makaleler

İnfantil hemanjiomların tedavisinde topikal beta-blokerlerin etkinliği

Gökçe Pınar REİS, Ali FETTAH, Ali AKYİĞİT, Atilla ÇAYIR, Burcu VOLKAN

Laodikeia Apollon Altarı Kabartmaları

Celal ŞİMŞEK

Solunum yolu örneklerinden izole edilen non-fermentatif gram negatif bakterilerin antibiyotik direnç dağılımları: altı yıllık analiz

Tuba MUDERRİS, Rahim ÖZDEMİR, Selçuk KAYA, Ayşegül AKSOY GÖKMEN, Bilal Olcay PEKER

Bir üniversite hastanesi personelinin Brusella hakkındaki bilgi, tutum ve davranışlarının değerlendirilmesi

Mert ÖZEN, Atakan YILMAZ, Reşad BEYOĞLU, Mert ÖZEN, ALTEN OSKAY

İskemik inmede ekokardiyografi bulgularının inme şiddeti, hemorajik transformasyon ve kısa dönem prognoz ile ilişkisi

Fettah EREN, Aydın YILDOĞAN, Güllü EREN, Ayşegül DEMİR, Kenan DEMİR

İntrakraniyal epidermoid tümörlerin cerrahi tedavisi: cerrahi olarak tedavi edilen 29 hastanın retrospektif analizi

Kadir OKTAY, Ebru GÜZEL, Adnan DEMİRCİ, Özlem Nuray SEVER, Vildan KAYA, Elif AKPINAR, Mustafa YILDIRIM, Aslan GÜZEL, Hakan SEÇKİN

Nötrofil- lenfosit oranı ve trombosit- lenfosit oranlarının çocuklardaki kistik fibroz dışı bronşektazinin akut alevlenmesinde potansiyel biyolojik gösterge olarak değerlendirmesi

Ayse Ayzıt KILINÇ, Gulizar ALİSHBAYLİ, Nursena KOLOGLU, Haluk ÇOKUĞRAŞ

İzole sıçan aortunda dobutaminin vazokonstriktör etkisinde beta adrenerjik reseptörler rol oynar

Hande Özge Altunkaynak ÇAMCA

Yumurta alerjisi olan çocuklarda kızamık-kızamıkçık-kabakulak aşılaması sonrası reaksiyon durumunun değerlendirilmesi

Şennur KELEŞ, Serkan FİLİZ

Hemifasiyal spazmlı hastalarda nörogörüntüleme bulguları

Eylem Özaydın Göksu, Fatma Genç, Burcu Yüksel,