Kolorektal kanserde evrelerine göre primer tümör lokasyonunun etkileri

Amaç: Bu çalışmanın amacı erken ve ileri evre kolon kanseri hastalarında tümör lokalizasyonunun etkilerini incelemektir. Gereç ve Yöntem: 2013-2017 arasında Adnan Menderes Üniversitesi'nin Tıbbi Onkoloji Bölümü’ne başvuran primer kolorektal kanser tanılı hasta retrospektif olarak tarandı ve 249 hasta çalışmaya dahil edildi. Bulgular: Erken evrede, sol taraftaki kolorektal kanserler erkeklerde anlamlı olarak daha yaygındı (p=0,027). Sağ taraftaki tümörlerde nüks kadın hastalarda daha erken gelişti (p=0,043). Kadın cinsiyet, genç yaş nüks süresi için bağımsız prognostik faktörlerdi. RAS mutasyonun olmasının veya mutasyon durumunun bilinmemesinin her iki taraftaki tümörler için olumsuz prognostik faktörler olduğu bulundu. Metastatik evrede, sol taraftaki tümörlerde RAS mutant olan hastaların yaşam süresi daha uzundu. (sırasıyla 49,0'a 25.5 ay, p

The effects of primary tumour location on patients with all stages of colorectal cancer

Purpose: The aim of this study was to examine the effects of tumor localization in early and advanced stage colon cancer patients. Materials and Methods: This retrospective study enrolled 249 primary colorectal cancer (CRC) patients at medical oncology department of Adnan Menderes University between 2013-2017. Results: In early stage, left sided tumors were significantly more common in males (p=0.027). In right sided tumours recurrence developed earlier in female patients (p=0.043) and female sex young age were unfavorable prognostic factors for the relapse time. Positive and unknown RAS mutation status were found to be unfavorable prognostic factors for both side. In metastatic stage, patients with RAS mutant left sided tumors lived longer than RAS negative patients (49.0 vs 25.5 months respectively, p

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