Nur OGUZ DAVUTOGLU, Hava ÜSKÜDAR TEKE, Fatih YAMAN, Neslihan ANDIC, Eren GUNDUZ

Perikard Tutulumu Olan Multiple Myelom Olgusu

Multipl miyelom (MM), tüm hematolojik kanserlerin yaklaşık %10'unu oluşturan kemik iliğinin atipik plazma hücre bozukluğudur. MM’da ekstramedüller hastalık %6-20 oranında görülürken kardiyak ve perikardiyal tutulum varlığı ise nadirdir. Kardiyak veya perikardiyal tutulum meydana geldiğinde, kalp tamponadına ilerleme hastaların %60'ında gerçekleşir. Biz de otolog kök hücre nakli sonrası çok nadir görülen perikard tutulumu ile nüks olan olguyu sunacağız.

Anahtar Kelimeler:

multiple myelom, relaps, perikardiyal tutulum

Multiple Myeloma Case with Pericardial Involvement

Multiple myeloma (MM) is an atypical plasma cell dyscrasia in the bone marrow (BM) which accounts for about 10% of all hematological malignancies. While extramedullary disease (EMD) is reported at a ratio of 6-20% in MM, cardiac and pericardial involvement is rare. In the event of cardiac or pericardiac involvement, on the other hand, progression into cardiac tamponade takes place in 60% of the patients. We will present a very rare case of recurrence with pericardial involvement after autologous stem cell transplantation

Keywords:

multiple myeloma, relapse, pericardial involvement,

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Referance1. Kyle RA, Rajkumar SV. Multiple myeloma. Blood 2008;111(6):2962–72.
Referance2. Chen T, Kim Taubman K, Xiao H et al. Cardiac tamponade in multiple myeloma: A pictorial case review of FDG PET/CT findings. Journal of Medical Imaging and Radiation Oncology 2020;64: 377–378.
Referance3. Abelman W, Virchis A, Yong K. Extramedullary myeloma representing as a pericardial effusion with tamponade: two case reports and a further review of 19 cases in the literature. Leuk Lymphoma 2005;46(1):137–42.
Referance4. Coakley M, Yeneneh B, Rosenthal A, et al. Extramedullary cardiac multiple myeloma-a case report and contemporary review of the literature. Clin Lymphoma Myeloma Leuk 2016;16(5):246–252.
Referance5. Skipina TM, Sane DC, Cui C et al. A plasma cell-based pericardial effusion leading to tamponade in a patient with multiple myeloma -a case report and review of the literature. Cardiovasc Pathol 2019; 40: 41–46.
Referans6. Arat M, Ulusoy V, Demirer T, et al. An unusual presentation of plasma cell dyscrasias: cardiac tamponade due to myelomatous infiltration. Leuk Lymphoma 2002;43(1):145–148.