Notch Sinyal Yolağı ve Karsinogenez / Notch Signaling Pathway and Carcinogenesis

Notch sinyal yolağı, gelişim döneminde hücre kaderinin belirlenmesinde rol oynayan bir mekanizmadır. Notch reseptörü boyunca komşu hücreler arasındaki sinyal alışverişi artar. Notch aktivitesi organ oluşumu ve morfogenezde rol oynayarak farklılaşma, çoğalma ve apoptozu etkiler. Son çalışmalar Notch sinyalinin hücre farklılaşması ve proliferasyonu ile apoptotik olaylarda rol oynadığını kanıtlanmıştır. Ayrıca kanserli hücrelerde Notch aktivasyonunun anormal hücre çoğalmasına neden olduğu görülmüştür. Notch ile hücre çoğalması arasında önemli bir bağlantı olduğu birçok çalışmada gösterilmiştir. Bu derlemede Notch sinyal yolağı elementleri, aktivasyonu ve kanseri hangi mekanizmalarla etkilediği ele alınmaktadır.

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Osmangazi Tıp Dergisi-Cover
  • ISSN: 1305-4953
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 2013
  • Yayıncı: Eskişehir Osmangazi Üniversitesi Rektörlüğü
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