Fezan Mutlu, Onur Armagan, Merih Ozgen, Ayse Merve Aydogan, Ali Uygur, Funda Berkan, Seda Oncel, Fulya Bakilan, Ozkan Alatas

Diz Osteoartritinde Su rekli ve Kesikli Ultrason Tedavilerinin Değ erlendirilmesi: Randomize ve Plasebo Kontrollu Bir Klinik Çalışma

Bu çalışma, diz osteoartritinde, terapotik sürekli, kesikli ve plasebo ultrason uygulamasının, klinik ve biyokimyasal etkinliğini karşılatırmak amacıyla yapılmıştır. Diz osteoartriti tanısı alan 30 hasta üç gruba ayrıldı. 1. gruba sürekli ultrason (1 MHz, 2 W / cm2); 2. gruba kesikli ultrason (1MHz,2W/cm2,1:4); 3. gruba ise plasebo ultrason tedavisi uygulandı. Tüm gruplar 10 gün (5 dakika/seans) tedavi aldı. Hastalar tedavi öncesi ve tedavi sonrası 1. ayda WOMAC, serum hs - CRP, COMP, MMP - 1, MMP - 3 ve idrar CTX - II düzeyleri ile değerlendirildi. Demografik özellikler karşılaştırıldığında, üç grup arasında yaş, vücut kitle indeksi ve radyolojik evreleme açısından istatistiksel olarak anlamlı bir fark bulunmadı ( p > 0.05 ). Klinik parametreler açısından, tedaviden sonraki ilk ayda, plasebo grubunda WOMAC sertlik dışında, her üç grupta iyileşme saptandı, ancak gruplar arasında istatistiksel olarak anlamlı bir fark gözlenmedi ( p > 0.05 ). Biyokimyasal parametrelerin 1. ay değerlendirilmesinde tedavi öncesi ve tedavi sonrası gruplar arasında anlamlı fark bulunmazken, grup 1 ve grup 3 arasında grup 3 lehine istatistiksel olarak anlamlı bir fark vardı ( p = 0.019 ). Diz OA’de tek başına ve kısa süreli uygulanan terapötik ultrasonun (sürekli/kesikli) klinik ve biyokimyasal belirteçler üzerine etkinliği gösterilememiştir.

Evaluation of Continuous and Pulsed Ultrasound Treatments on Knee Osteoarthritis: A Randomized and Placebo-Controlled Study

This study evaluates effects of therapeutic ultrasound (continue, pulsed, placebo) treatment on the clinical andbiochemical parameters in knee osteoarthritis. 30 patients (30-70 aged) diagnosed with knee osteoarthritis were randomly separatedinto three groups. The 1st group includes 10 patients given continue ultrasound treatment (1 MHz, 2W/cm2), the 2nd group consistsof 10 patients given pulsed ultrasound treatment (1MHz, 2 W/cm2, 1:4) and 3th group includes 10 patients given placebo ultrasoundtreatment (switch off). The patients were assessed before and one month after the treatment with WOMAC, COMP, Hs CRP, MMP1, MMP-3 levels in serum and CTX-II levels in urine. When the demographic characteristics were compared, no statisticallysignificant difference was found between the three groups in terms of age, body mass index and radiological staging ( p > 0.05).In terms of clinical parameters, there was an improvement in all three groups in the first month after treatment except WOMACstiffness in pulsed and placebo groups, although no statistically significant difference was observed between the groups ( p >0.05). In the evaluation of biochemical parameters, there was no significant difference between the groups in terms of pre-treatmentand post-treatment 1 month, whereas there was a statistically significant difference between the group 1 and group 3 in favor ofgroup 3 ( p = 0.019). The efficacy of therapeutic US (continuous / pulsed) which was applied short term and alone, on clinical andbiochemical markers in knee osteoartrithis, has not been demonstrated.

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