Çocuklarda Baş-Boyun Bo lgesi Haricinde Oluşan Tu mo rlerin Tedavisinde Kullanılan Antineoplastik Ajanların Diş Gelişimi Ü zerindeki Etkileri

Bu çalışmanın amacı; çocukluk çağı tümörlerinde baş-boyun bölgesi haricinde oluşan neoplazmların tedavisinde kullanılan antineoplastik ajanların diş ve çene gelişimine etkisini araştırmaktır. Bu çalışma, tümör lokalizasyonu baş-boyun bölgesi dışında oluşan, yaşları 3 ve 14 arasında değişen, kemoterapi uygulanan ve başka bir sistemik hastalığı olmayan 30 hasta üzerinde yapılmıştır. Bu hastalardan tedavinin başlangıcında, tedavinin sonunda ve tedavi bitiminden 12 ay sonra periapikal ve panoramik radyografiler çekilerek diş ve diş köklerinin uygulanan kemoterapötik ajanlardan etkilenip etkilenmediği incelenmiştir. Hastalarda sürmede gecikme, kök agenezi, kökte incelme, apeksifikasyonda gecikme ve fizyolojik kök rezorpsiyonunda gecikme görülmüştür. Uygulanan kemoterapinin süresinin ve neoplazmların tiplerinin oluşan komplikasyonlar üzerinde bir etkisi olmadığı belirlenmiştir. Çocuklarda baş-boyun bölgesi dışında kalan kanserlerin tedavisinde kullanılan antineoplastik ajanların geç dönemde diş ve kök gelişimi üzerinde olumsuz etkileri görülebilir.

The Effects of the Antineoplastic Agents Üsed for the Treatment of Non-Head and Neck Tumors on the Teeth Development in Children

The aim of the present study is to examine the effects of the antineoplastic agents used for the treatment of non-head and neck tumors on the tooth and jaw development in children. This study has been carried out on 30 patients whose ages were between 3 and 14. The subjects had no systemic conditions and they were receiving chemotherapy for tumors that were localized other than the head and neck region. Periapical and panoramic imaging were done before the treatment, after the treatment and at the end of the 12 months in order to examine the effects of the chemotherapeutic agents on the tooth and jaw development. Delayed eruption, root agenesis, thinning of the roots, delayed apexification and delayed physiologic root resorption were observed in the subjects. The duration of the chemotherapy and the type of neoplasm did not have any effect on the developmental complications. The antineoplastic agents used for the treatment of non-head and neck tumors in children may have negative late effects on the tooth and root development.

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