Zafer AYBEK, Neşe ÇALLI, Ender DÜZCAN, Hatice BAYRAMOĞLU, Tarık YONGUÇ

Varikoselde adrenal ve renal metabolitlerin testis ısısı ve morfolojisi üzerine etkileri

Varikoselde testiküler disfonksiyonun sebebi olarak çeşitli hipotezler ileri sürülmektedir. Bu çalışmanın amacı renal ve adrenal metabolitlerin internal spermatik ven yolu ile testiste morfolojik değişikliklere yol açtığı hipotezini araştırmaktı.Bu çalışma, kontrol (Sham) (Grup I, n: 5), deneysel olarak oluşturulmuş sol varikosel (Grup II, n: 7) ve deneysel sol varikosel + adrenalektomi + nefrektomi (Grup III, n: 9) uygulanan toplam 21 on haftalık ratları içeren 3 grupta planlandı. Operasyondan 10 hafta sonra her bir ratm veziküla seminalis, epididim, testis ağırlıktan ve intratestiküler, intraperitoneal ışılan ölçüldü. Aynca epididimal sperm aspirasyonu yapıldı ve histolojik inceleme için testis biyopsileri alındı. İntraabdominal ve intratestiküler ısılar arasındaki farklar (delta T) grup II ve III ile I arasında anlamlı farklılık gösteriyordu (p

Effects of adrenal and renal metabolites on testicular temperature and morphology in varicocele

The aim of this study was to research for the validity of the hypothesis, which claims that the reflux of renal and adrenal metabolites by internal spermatic vein through testis causes morphological changes.The study was planned for three groups as sham (Group I, n: 5 ), experimantally induced left varicocele (Group II, n: 7), experimantally induced left varicocele + left adrenalectomy + left nephrectqmy (Group III, n:9), containing 21 adolescent rats, totally. Ten weeks after the gperation thé wheights, ef vgsieula seminalis, epididiym, testis and tatratesticular totraperitoneal temperatures of each rat were measured. Additionally epididimal sperm aspiration was performed and testicular biopsy specimens were obtained for histological examination. The differences between intraabd,p,minal and intratesticular temperatures (delta T) were statistically significantbetween the groups II-III and I (p<0.05). Histological examination showed that the germ cell desquamation was present in 5 (71,4%) and 1 (11.1%) of the rats in-groups II and III, respectively. Also, Leydig cell changes were more prominent in groups II and III than group I.The results of our study have shown that although elevated intratesticular temperature was responsible for the morphological alteration of testicular tissue in varicocele, some adrenal and/or renal factors also contribute to this process.