Devrim SARIBAL, Eyüp Murat KANBER

117124

Variköz Ven Hastalarında Doku Eser Element Düzeylerinin Atomik Absorbsiyon Spektrometresi ile Tayini

Amaç: Alt ekstremite variköz ven varlığı dünyada çok sayıda kişiyi etkileyen bir patolojidir. Etyolojisinde mekanik ve intrinsik faktörlerin varlığı ileri sürülmektedir. Bu çalışma ile, variköz ven dokularında eser elementler Zn, Cu ve Fe düzeyinin ölçümüyle lokal etkenler konusunda bir değerlendirme yapmayı amaçladık. Materyal ve Metod: Çalışmamız alt ekstremitede primer varis tanısı nedeniyle opere edilecek 40 kişi ve koroner arter bypass greft operasyonu geçirecek, sağlıklı Vena safena magnaya sahip 40 kişi olmak üzere 80 birey üzerinde gerçekleştirildi. Alınan ven doku örneklerinde eser elementlerden Zn, Cu ve Fe ölçümleri yapıldı. Bulgular: Kontrol grubu ile karşılaştırıldığında Zn düzeyleri çalışma grubunda istatistiksel olarak anlamı seviyede düşük, Fe düzeyleri ise anlamlı olarak yüksek saptanmıştır. Cu düzeyleri çalışma grubunda kontrol grubuna kıyasla yüksek olmasına rağmen, bu fark anlamlı değildir. Çalışma grubunda, eser elementler açısından herhangi bir korelasyon gözlenmemiştir. Sonuç: Variköz ven grubu doku örneklerinde düşük saptanan Zn düzeylerinin azalmış antioksidan aktivite ile ilişkili olduğu düşünülmüştür. Artan Cu düzeyi ise, artmış kollajen ve elastin yapımı nedenli olabilir. Çalışma grubunda dokularda artmış Fe birikiminin, hasarlı dokuya çökerek oksidatif stresi tetiklediğini de düşünmekteyiz.
Anahtar Kelimeler:

variköz ven, eser element, demir, bakır

Determination of Tissue Trace Element Levels with Atomic Absorption Spectrometry in Varicose Vein Patients

Objective: The presence of varicose veins in the lower extremities is a pathology affecting many people in the world. In the etiology, presence of mechanical and intrinsic factors is suggested. In this study, we aimed to evaluate the local factors by measuring trace elements, Zn, Cu and Fe levels in varicose vein tissue samples.Materials and Methods: Our study was carried out on 40 subjects, 40 of whom were operated for coronary artery bypass graft having healthy saphenous vein, and 40 with primary varicose veins in lower extremity. Zn, Cu and Fe were measured in venous tissue samples.Results: Zn levels were significantly lower in the study group whereas Fe levels were significantly higher in the study group compared to the control group. Although Cu levels were higher in the study group compared to the control group, this difference was not significant. In the study group, no correlation was observed in terms of trace element levels. Conclusion: Low levels of Zn in tissue samples were thought to be associated with decreased antioxidant activity. Increased Cu level may be due to increased collagen and elastin production. We assume that increased Fe accumulation in tissues in the study group was triggered oxidative stress by adsorbing on the damaged tissue.
Keywords:

varicose vein trace elements, iron, copper, zinc,

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Namık Kemal Tıp Dergisi-Cover
  • ISSN: 2587-0262
  • Başlangıç: 2013
  • Yayıncı: Erkan Mor
Arşiv
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