SARS-CoV-2’ye Karşı Doğal Terapötiklerin Potansiyeli: Fenolik Bileşikler ve Terpenler

2019 yılının sonlarında Çin’de ortaya çıkan şiddetli, koronavirüs akut solunum yolu sendromu-koronavirüs-2’nin (SARS-CoV-2) neden olduğu koronavirüs hastalığı-2019, insan yaşamının hemen hemen her sektörünü etkileyen ve dünya ekonomisine büyük zarar veren benzeri görülmemiş bir küresel sağlık krizi meydana getirmiştir. SARS-CoV-2, yalnızca üst solunum yolu enfeksiyonuna neden olmakla kalmayıp aynı zamanda alt solunum yolu mukozası tutulumu da yapabilen ve bu sebeple pnömoniye neden olarak bazı hastalarda ölüme yol açan viral bir solunum yolu virüsüdür. Şu anda SARS-CoV-2 tedavisi için kanıtlanmış bir ilaç olmaması ile birlikte, tedavi için birçok kimyasal ve doğal aktif bileşik araştırmacılar tarafından test edilmiştir. Bu bitkisel bazlı antiviraller, daha az toksik oldukları ve enfeksiyöz mikroorganizmalar tarafından direnç geliştirilmesi daha düşük olasılıklı olduğu için birçok araştırmanın konusu olmuştur. Doğal terapötiklerin viral replikasyonu engellediği de birçok çalışmada bildirilmiştir. Bu derlemede, antiviral aktiviteye sahip olduğu bilinen doğal terapötikler olan fenolik bileşikler ve terpenler, SARS-CoV-2 tedavisinde kullanım potansiyelleri açısından ele alınmıştır.

Potential of Natural Therapeutics Against SARS-CoV-2: Phenolic Compounds and Terpenes

Coronavirus disease-2019 caused by severe-coronavirus acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) which emerged in China in late 2019 has created an unprecedented global health crisis affecting every sector of human life and causing great damage to the world economy. SARS CoV-2 is a viral respiratory tract virus that not only causes upper respiratory tract infection but also causes pneumonia and therefore mortality in some patients. There is currently no proven drug for the treatment of SARS-CoV-2. Many chemical and natural active compounds have been testing by the researchers for the treatment. These herbal-based antivirals have been the subject of many studies as they are less toxic and less likely to develop resistance by infectious microorganisms. It has been reported in many studies that natural therapeutics inhibit viral replication. In this review, phenolic compounds and terpenes, which are natural therapeutics known to have antiviral activity, have been evaluated for their potential in the treatment of SARS-CoV-2.

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