GEBELERDE VE YENİDOĞANLARDA VİTAMİN B12 DÜZEYİNİN DEĞERLENDİRİLMESİ

Amaç: Gebelerde vitamin B12 eksikliği yalnızca anneleri değil aynı zamanda bebeklerini de etkileyen önemli bir sağlık sorunudur. Her ne kadar vitamin B12 eksikliği tüm dünyada ve tüm yaş gruplarında görülse de sosyoekonomik düzeyi düşük toplumlarda görülme sıklığı daha yüksektir. Bu çalışmanın amacı, İstanbul’un sosyo-ekonomik düzeyi düşük bir bölgesi olan Bağcılar’da, gebe kadınların vitamin B12 düzeylerini belirlemek, annelerin vitamin B12 düzeyinin yenidoğan bebeklerin düzeyine etkisini ve vitamin B12 eksikliği için risk faktörlerini belirlemektir. Materyal ve Metot: Bu çalışma Mart 2016 ve Mart 2017 tarihleri arasında 71 gebe ve 71 yenidoğan üzerinde gerçekleştirildi. Yaş, cinsiyet, ağırlık, gebelik haftası, gebelik boyunca alınan kilo, vücut kitle endeksi, doğum sayısı, sosyoekonomik durum, diyet, gebelikte vitamin alımı kaydedildi. Tüm katılımcılardan tam kan sayımı ve vitamin B12 için kan örnekleri alındı. Gebe kadınlar ve yenidoğan bebekler vitamin B12 düzeylerine göre sınıflandırıldı. Vitamin B12 eksikliği için risk faktörleri araştırıldı. Bulgular: Gebe kadınların ortalama vitamin B12 düzeyi 172,96 ± 103 pg/ml idi. B12 yetersizliği (

ASSESSMENT OF THE VITAMIN B12 STATUS OF PREGNANT WOMEN AND THEIR INFANTS

Aim: Vitamin B12 deficiency is an important problem inpregnancy because it affects not only mothers but alsotheir infants. Although vitamin B12 deficiency is seen allover the world and all age groups, its frequency is muchhigher in population which has low socio-economic level.The aim of this study was to evaluate the maternal vitaminB12 status and their effect on neonatal vitamin B12 statusand to detect risk factors for vitamin B12 deficiency inBağcılar where is a low socio-economic region in Istanbul.Materials and Methods: A total of 71 pregnant women and71 infants were included in this study between March 2016and March 2017. Age, gender, weight, gestational age,weight gain during pregnancy, body mass index (BMI),number of parity, socio-economic status, diet, daily vitaminintake were recorded. Blood samples for whole bloodcount and vitamin B12 were taken all subjects. Thepregnant women and newborns were divided into groupsbased on their vitamin B12 levels. The risk factors wereanalyzed for vitamin B12 deficiency.Results: The mean vitamin B12 level was 172.23±102pg/ml for pregnant women. The number of pregnantwomen in deficient group (

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  • Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009;89(Suppl):693S-6S.
  • Smith J, Coman D. Vitamin B12 Deficiency: an Update for the General Paediatrician. Pediat Therapeut. 2014:188.
  • Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficiency in children and adolescents. J Pediatr. 2001;138:10-7.
  • Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349:g5226.
  • Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev. 2008;66(5):250-5
  • Roumeliotis N, Dix D, Lipson A. Vitamin B12 deficiency in infants secondary to maternal causes. CMAJ. 2012;184(14):1593-8.
  • Global database on Body Mass Index, WHO. Available from:http://apps.who.int/bmi/index.jsp?introPage=intro.
  • Institute of Medicine. Weight gain during pregnancy: reexamining the guidelines. Washington, DC: National Academies Press; 2009.
  • De Benoist B. Conclusions of a WHO Technical Consultation on Folate and Vitamin B12 Deficiencies. Food Nutr Bull. 2008;29:238-44.
  • Institute of Medicine of the National Academies of Science. Dietary reference intake for thiamine, riboflavin, niacin, vitamin B6, folate, vitamin B12, panthotenic acid, biotine and choline. Washington, DC: National Academies Press, 1998.
  • 1Koebnick C, Heins UA, Dagnelie PC, Wickramasinghe SN, Ratnayaka ID, Hothorn T, et al. Longitudinal Concentrations of Vitamin B12 and Vitamin B12-binding Proteins during Uncomplicated Pregnancy. Clinical Chemistry. 2002;48:928-33.
  • Devalia V, Hamilton MS, M. Molloy AM. British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166: 496–513
  • Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull. 2008;29:S101-11; discussion S112-5.
  • Ray JG, Goodman J, O'Mahoney PR, Mamdani MM, Jiang D. High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification. QJM. 2008;101:475-7.
  • García-Casal MN, Osorio C, Landaeta M, Leets I, Matus P, Fazzino F, et al. High prevalence of folic acid and vitamin B12 deficiencies in infants, children, adolescents and pregnant women in Venezuela. Eur J Clin Nutr. 2005;59:1064-70.
  • Vitamin B (12) intake and status in early pregnancy among urban South Indian women. Samuel TM, Duggan C, Thomas T, Bosch R, Rajendran R, Virtanen SM, et al. Ann Nutr Metab. 2013;62:113-22.
  • VanderJagt DJ, Ujah IAO, Ikeh EI, Bryant J, Pam V, Hilgart A, et al. Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin. Obstet and Gynecol. 2011;2011:365894.
  • Sukumar N, Rafnsson SB, Kandala NB, Bhopal R, Yajnik CS, Saravanan P. Prevalence of vitamin B-12 insufficiency during pregnancy and its effect on offspring birth weight: a systematic review and metaanalysis. Am J Clin Nutr. 2016;103:1232-51.
  • Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, et al. High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa province of Turkey. Eur J Nutr. 2006;45:291-7.
  • Önal H, Adal E, Öner T, Önal Z, Ahmet Aydın A. An important problem in developing countries: maternal and neonatal vitamin B12 deficiency. Turk Arch Ped. 2010;45:242-5.
  • Halicioglu O, Sutcuoglu S, Koc F, Ozturk C, Albudak E, Colak A, et al.. Vitamin B12 and folate statuses are associated with diet in pregnant women, but not with anthropometric measurements in term newborns. J Matern Fetal Neonatal Med. 2012;25:1618-21.
  • Yılmaz Keskin E, Demir B, İğde M, Öksüz BG. Prevalence of Vitamin B12 Deficiency among Pregnant Women in Samsun Province of Turkey. Cukurova Med J. 2014;39:840-7.
  • Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A, et al. Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr. 2006;60:791-801.
  • Rogne T, Tielemans MJ, Foong-Fong Chong M, Yajnik CS, Krishnaveni GV, Poston L, et al. Maternal vitamin B12 in pregnancy and risk of preterm birth and low birth weight: A systematic review and individual participant data meta-analysis. Am J Epidemiol. 2017;185:212-23.
  • Chen LW, Lim AL, Colega M, Tint MT, Aris IM, Tan CS, et al. Maternal folate status, but not that of vitamins B-12 or B-6, is associated with gestational age and preterm birth risk in a multiethnic Asian population. J Nutr. 2015;145:113-20.
  • Smith AD, Warren MJ, Refsum H. Vitamin B 12. Adv Food Nutr Res. 2018;83:215-79.
  • Papp F, Racz G, Lenart I, Kobor J, Bereczki C, Karg E, Barath A. Maternal and neonatal vitamin B12 deficiency detected by expanded newborn screening. Orv Hetil. 2017;158:1909-18.